Kuwabara S, Watanabe Y, Sato A, Nakajima M, Hirayama K
Department of Neurology, Chiba Emergency Medical Center.
Rinsho Shinkeigaku. 1990 Sep;30(9):956-60.
Somatosensory evoked potentials to median nerve stimulations were recorded in 21 patients with hypoxic coma within 24 hours from the onset. According to the neurologic prognosis, the patients were classified into 4 groups, such as I, complete recovery (5 patients), II, partial recovery (3 patients), III, vegetable state (8 patients), IV, brain death (5 patients). Measurements performed include central conduction time (N13-N20 interpeak latency) and amplitude ratio between N20 and P25. As N20 and P25 disappeared in 3 of 8 vegetable patients and all of brain death patients, disappearance of these waves indicates poor neurologic prognosis. Central conduction time showed no significant difference. Amplitude ratio between N20 and P25 (P25/N20) revealed significant decrease in vegetative patients for normal control subjects, complete recovery and partial recovery patients (p less than 0.05). Measurement of this ratio in early phase is useful to predict neurologic outcome in patients with hypoxic coma.
在21例缺氧性昏迷患者发病后24小时内记录了正中神经刺激的体感诱发电位。根据神经学预后，将患者分为4组，如I组，完全恢复（5例）；II组，部分恢复（3例）；III组，植物状态（8例）；IV组，脑死亡（5例）。进行的测量包括中枢传导时间（N13 - N20峰间潜伏期）以及N20与P25之间的波幅比。由于8例植物状态患者中有3例以及所有脑死亡患者的N20和P25消失，这些波的消失表明神经学预后不良。中枢传导时间无显著差异。与正常对照受试者、完全恢复和部分恢复患者相比，植物状态患者的N20与P25波幅比（P25/N20）显著降低（p小于0.05）。在早期测量该比值有助于预测缺氧性昏迷患者的神经学结局。
