悬雍垂腭咽成形术对中重度阻塞性睡眠呼吸暂停低通气综合征患者血流介导的血管舒张功能的影响
Effect of Han-uvulopalatopharyngoplasty on flow-mediated dilatation in patients with moderate or severe obstructive sleep apnea syndrome.
作者信息
Yang Hai-bo, Wang Ying, Dong Ming-min
机构信息
Department of Cardiology, First Affiliated Hospital of Zhengzhou University, China.
出版信息
Acta Otolaryngol. 2012 Jul;132(7):769-72. doi: 10.3109/00016489.2011.653672. Epub 2012 Jun 1.
CONCLUSION
Flow-mediated dilatation (FMD) is decreased in patients with moderate or severe obstructive sleep apnea syndrome (OSAS), and Han-uvulopalatopharyngoplasty (H-UPPP) can improve FMD.
OBJECTIVE
To evaluate FMD in patients with moderate or severe OSAS and observe the effect of H-UPPP on FMD in these patients.
METHODS
Forty-nine patients who were first diagnosed with moderate or severe OSAS by polysomnography (PSG) and had no other diseases served as the experimental group, and 35 individuals with normal PSG as the control group. FMD was measured with high-resolution B-mode ultrasonography in the two groups. PSG and FMD were again performed in the experimental group 6 months after H-UPPP.
RESULTS
FMD was significantly lower in the experimental group than in the control group (6.5 ± 2.1% vs 11.2 ± 2.9%, p < 0.01). FMD was significantly improved 6 months after H-UPPP compared with preoperative FMD (9.7 ± 2.7% vs 6.5 ± 2.1%, p < 0.01).
结论
中重度阻塞性睡眠呼吸暂停综合征（OSAS）患者的血流介导的血管舒张功能（FMD）降低，而韩式悬雍垂腭咽成形术（H-UPPP）可改善FMD。
目的
评估中重度OSAS患者的FMD，并观察H-UPPP对这些患者FMD的影响。
方法
49例首次经多导睡眠图（PSG）诊断为中重度OSAS且无其他疾病的患者作为实验组，35例PSG正常的个体作为对照组。两组均采用高分辨率B型超声测量FMD。实验组在H-UPPP术后6个月再次进行PSG和FMD检测。
结果
实验组的FMD显著低于对照组（6.5±2.1%对11.2±2.9%，p<0.01）。与术前FMD相比，H-UPPP术后6个月FMD显著改善（9.7±2.7%对6.5±2.1%，p<0.01）。
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