Yang Haibo, Wang Ying, Dong Mingmin
Department of Cardiology, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2012 May;26(9):402-3, 407.
This study evaluates the effects of H-uvulopalatopharyngoplasty (H-UPPP) on endothelial function by endothelium dependent flow-mediated dilation(FMD) in patients with moderate to severe obstructive sleep apnea syndrome (OSAHS).
Forty-five healthy subjects and 49 patients with moderately to severe OSAHS who desired H-UPPP were prospectively enrolled. FMD was measured by high-resolution B-mode ultrasonography. All subjects participated in sleep studies. These studies were repeated 6 months after H-UPPP in patients with moderately to severe OSAHS.
There was significant difference in FMD between patients with moderately to severe OSAHS and healthy subjects at baseline (6.5 +/- 2.1)% vs (11.2 +/- 3.1)% (P < 0.01). FMD increased from (6.5 +/- 2.1)% to (9.7 +/- 2.7)% 6 months after H-UPPP in patients with moderately to severe OSAHS (P < 0.01).
FMD is decreased in patients with moderately to severe OSAHS, H-UPPP treatment of these patients leads to improvement of FMD.
本研究通过内皮依赖性血流介导的血管舒张功能（FMD）评估悬雍垂腭咽成形术（H-UPPP）对中重度阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患者内皮功能的影响。
前瞻性纳入45名健康受试者和49名希望接受H-UPPP治疗的中重度OSAHS患者。采用高分辨率B型超声测量FMD。所有受试者均参与睡眠研究。中重度OSAHS患者在接受H-UPPP治疗6个月后重复上述研究。
中重度OSAHS患者与健康受试者在基线时的FMD存在显著差异（分别为6.5±2.1%和11.2±3.1%，P<0.01）。中重度OSAHS患者在接受H-UPPP治疗6个月后，FMD从6.5±2.1%增加至9.7±2.7%（P<0.01）。
中重度OSAHS患者的FMD降低，H-UPPP治疗可改善这些患者的FMD。
