Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA.
Prog Mol Biol Transl Sci. 2012;108:293-322. doi: 10.1016/B978-0-12-398397-8.00012-5.
Coffee is one of the most widely consumed beverages in the world. Its widespread popularity and availability has fostered public health concerns of the potential health consequences of regular coffee consumption. Epidemiological studies of coffee intake and certain health outcomes have been inconsistent. The precise component of coffee potentially contributing to development of these conditions also remains unclear. One step toward addressing the challenges in studying the impact coffee has on health is a better understanding of the factors contributing to its consumption and physiological effects. This chapter focuses on those factors that are genetically determined and briefly summarizes progress in applying this knowledge to epidemiological studies of coffee and disease.
咖啡是世界上最广泛饮用的饮料之一。它的广泛普及和易得性引起了公众对经常喝咖啡可能带来健康后果的关注。关于咖啡摄入量和某些健康结果的流行病学研究结果并不一致。咖啡中可能导致这些情况发生的确切成分也不清楚。解决研究咖啡对健康影响的挑战的一个步骤是更好地了解导致其消费和生理效应的因素。本章重点介绍那些由遗传决定的因素，并简要总结了将这些知识应用于咖啡和疾病的流行病学研究的进展。
