百日咳毒素和破伤风毒素对完整的和透化的牛肾上腺嗜铬细胞诱发的儿茶酚胺释放的抑制作用。
The inhibition by pertussis and tetanus toxins of evoked catecholamine release from intact and permeabilized bovine adrenal chromaffin cells.
作者信息
Bansal M K, Phillips J H, van Heyningen S
机构信息
Department of Biochemistry, University of Edinburgh, UK.
出版信息
FEBS Lett. 1990 Dec 10;276(1-2):165-8. doi: 10.1016/0014-5793(90)80533-o.
Pertussis toxin stimulates both basal and nicotine-evoked catecholamine secretion from intact bovine adrenal chromaffin cells, as well as Ca2(+)-evoked release from permeabilized cells. Tetanus toxin inhibits all these effects; it reduces the secretion of intact cells treated with pertussis toxin to the basal level, and decreases by about 50% Ca2(+)-evoked release from permeabilized cells whether or not previously stimulated by pertussis toxin.
百日咳毒素可刺激完整牛肾上腺嗜铬细胞的基础儿茶酚胺分泌以及尼古丁诱发的儿茶酚胺分泌，还可刺激通透细胞的Ca2(+)诱发释放。破伤风毒素可抑制所有这些效应；它将经百日咳毒素处理的完整细胞的分泌减少至基础水平，并使通透细胞的Ca2(+)诱发释放减少约50%，无论该通透细胞此前是否受到百日咳毒素的刺激。
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