Pertussis toxin stimulates delayed-onset, Ca2+-dependent catecholamine release and the ADP-ribosylation of a 40 kDa protein in bovine adrenal chromaffin cells.

作者信息

Brocklehurst K W, Pollard H B

机构信息

Laboratory of Cell Biology and Genetics, National Institute of Diabetes, and Digestive and Kidney Diseases, Bethesda, MD 20892.

出版信息

FEBS Lett. 1988 Jul 18;234(2):439-45. doi: 10.1016/0014-5793(88)80133-9.

Pertussis toxin was found to stimulate catecholamine release from bovine adrenal chromaffin cells in a Ca2+-dependent manner and in the absence of any stimulatory or inhibitory agonists for this cell. The release of catecholamine was associated with the ADP-ribosylation of an approx. 40 kDa protein present in the total membrane fraction. These results are consistent with the existence of an exocytosis-linked G-protein.