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Pertussis toxin stimulates delayed-onset, Ca2+-dependent catecholamine release and the ADP-ribosylation of a 40 kDa protein in bovine adrenal chromaffin cells.

作者信息

Brocklehurst K W, Pollard H B

机构信息

Laboratory of Cell Biology and Genetics, National Institute of Diabetes, and Digestive and Kidney Diseases, Bethesda, MD 20892.

出版信息

FEBS Lett. 1988 Jul 18;234(2):439-45. doi: 10.1016/0014-5793(88)80133-9.

DOI:10.1016/0014-5793(88)80133-9
PMID:3391283
Abstract

Pertussis toxin was found to stimulate catecholamine release from bovine adrenal chromaffin cells in a Ca2+-dependent manner and in the absence of any stimulatory or inhibitory agonists for this cell. The release of catecholamine was associated with the ADP-ribosylation of an approx. 40 kDa protein present in the total membrane fraction. These results are consistent with the existence of an exocytosis-linked G-protein.

摘要

相似文献

1
Pertussis toxin stimulates delayed-onset, Ca2+-dependent catecholamine release and the ADP-ribosylation of a 40 kDa protein in bovine adrenal chromaffin cells.
FEBS Lett. 1988 Jul 18;234(2):439-45. doi: 10.1016/0014-5793(88)80133-9.
2
Pertussis toxin facilitates secretagogue-induced catecholamine release from cultured bovine adrenal chromaffin cells.
Biochem Biophys Res Commun. 1987 Apr 29;144(2):907-14. doi: 10.1016/s0006-291x(87)80050-5.
3
The inhibition by pertussis and tetanus toxins of evoked catecholamine release from intact and permeabilized bovine adrenal chromaffin cells.百日咳毒素和破伤风毒素对完整的和透化的牛肾上腺嗜铬细胞诱发的儿茶酚胺释放的抑制作用。
FEBS Lett. 1990 Dec 10;276(1-2):165-8. doi: 10.1016/0014-5793(90)80533-o.
4
Neuropeptide Y inhibits pertussis toxin-catalyzed ADP-ribosylation in bovine adrenal chromaffin cell membranes.神经肽Y抑制牛肾上腺嗜铬细胞膜中百日咳毒素催化的ADP核糖基化。
Life Sci. 1993;52(25):PL285-90. doi: 10.1016/0024-3205(93)90694-x.
5
Prostaglandin E receptors in bovine adrenal medulla are coupled to adenylate cyclase via Gi and to phosphoinositide metabolism in a pertussis toxin-insensitive manner.牛肾上腺髓质中的前列腺素E受体通过Gi与腺苷酸环化酶偶联，并以百日咳毒素不敏感的方式与磷酸肌醇代谢偶联。
J Biol Chem. 1989 Mar 5;264(7):3916-23.
6
A pertussis-toxin-sensitive protein controls exocytosis in chromaffin cells at a step distal to the generation of second messengers.一种对百日咳毒素敏感的蛋白质在第二信使产生的下游步骤控制嗜铬细胞中的胞吐作用。
Biochem J. 1991 Mar 1;274 ( Pt 2)(Pt 2):339-47. doi: 10.1042/bj2740339.
7
Sodium fluoride mimics the effect of prostaglandin E2 on catecholamine release from bovine adrenal chromaffin cells.氟化钠模拟前列腺素E2对牛肾上腺嗜铬细胞儿茶酚胺释放的作用。
J Neurochem. 1991 Jan;56(1):44-51. doi: 10.1111/j.1471-4159.1991.tb02560.x.
8
Effects of pertussis toxin on the affinity of exocytosis for Ca2+ in bovine adrenal chromaffin cells.百日咳毒素对牛肾上腺嗜铬细胞胞吐作用与Ca2+亲和力的影响。
Neurosci Lett. 1990 Mar 2;110(1-2):167-71. doi: 10.1016/0304-3940(90)90806-k.
9
Neuropeptide Y inhibits forskolin-stimulated adenylate cyclase in bovine adrenal chromaffin cells via a pertussis toxin-sensitive process.神经肽Y通过一种对百日咳毒素敏感的过程抑制牛肾上腺嗜铬细胞中福斯高林刺激的腺苷酸环化酶。
J Pharmacol Exp Ther. 1992 Dec;263(3):1479-86.
10
Botulinum toxin-induced ADP-ribosylation and inhibition of exocytosis are unrelated events.肉毒杆菌毒素诱导的ADP核糖基化与胞吐作用的抑制是不相关的事件。
FEBS Lett. 1988 Oct 10;238(2):277-80. doi: 10.1016/0014-5793(88)80496-4.

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3
Multiple GTP-binding proteins from cholinergic synaptic vesicles.
来自胆碱能突触小泡的多种GTP结合蛋白。
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4
A pertussis-toxin-sensitive protein controls exocytosis in chromaffin cells at a step distal to the generation of second messengers.一种对百日咳毒素敏感的蛋白质在第二信使产生的下游步骤控制嗜铬细胞中的胞吐作用。
Biochem J. 1991 Mar 1;274 ( Pt 2)(Pt 2):339-47. doi: 10.1042/bj2740339.
5
Pertussis toxin stimulation of catecholamine release from adrenal medullary chromaffin cells: mechanism may be by direct activation of L-type and G-type calcium channels.百日咳毒素刺激肾上腺髓质嗜铬细胞释放儿茶酚胺：其机制可能是直接激活L型和G型钙通道。
J Membr Biol. 1991 May;122(1):23-31. doi: 10.1007/BF01872736.