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干细胞子宫内膜重建。

Endometrial reconstruction from stem cells.

机构信息

The Ritchie Centre, Monash Institute of Medical Research, Clayton, Victoria, Australia.

出版信息

Fertil Steril. 2012 Jul;98(1):11-20. doi: 10.1016/j.fertnstert.2012.05.004. Epub 2012 May 30.

Abstract

Adult stem cells have been identified in the highly regenerative human endometrium on the basis of their functional attributes. They can reconstruct endometrial tissue in vivo suggesting their possible use in treating disorders associated with inadequate endometrium. The identification of specific markers for endometrial mesenchymal stem cells and candidate markers for epithelial progenitor cells enables the potential use of endometrial stem/progenitor cells in reconstructing endometrial tissue in Asherman syndrome and intrauterine adhesions.

摘要

基于其功能特性,已在高度再生的人类子宫内膜中鉴定出成体干细胞。它们可以在体内重建子宫内膜组织,这表明它们可能用于治疗与子宫内膜不足相关的疾病。鉴定出子宫内膜间充质干细胞的特异性标志物和上皮祖细胞的候选标志物,使子宫内膜干细胞/祖细胞在重建 Asherman 综合征和宫腔粘连的子宫内膜组织中具有潜在的应用价值。

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