Sánchez-Pedrosa G, Garutti I, Moraga F J G, Orozco H D
Servicio de Anestesia y Reanimación, Hospital General Universitario Gregorio Marañón, Madrid, España.
Rev Esp Anestesiol Reanim. 2012 May;59(5):267-75. doi: 10.1016/j.redar.2012.04.008. Epub 2012 May 31.
There has been growing concern over the last few years on the effect that the anaesthetic drugs used during oncological surgery could have on long-term tumour progression. In laboratory studies, it has been observed how some substances used during the anaesthetic procedure influence tumour immunosurveillance, cell proliferation or tumour angiogenesis processes. The possible clinical relevance of the anaesthetic technique used as regards long-term tumour progression and survival is still to be determined. However, based on retrospective studies, it appears that those anaesthetic techniques combined with the use of regional anaesthesia and analgesia may be beneficial compared to those that are maintained on the use of opioids. Further research should help to clarify the long-term clinical relevance of the anaesthetic process during oncological surgery.
在过去几年里，人们越来越关注肿瘤手术中使用的麻醉药物对肿瘤长期进展的影响。在实验室研究中，已经观察到麻醉过程中使用的一些物质如何影响肿瘤免疫监视、细胞增殖或肿瘤血管生成过程。麻醉技术在长期肿瘤进展和生存方面的潜在临床相关性仍有待确定。然而，基于回顾性研究，与单纯使用阿片类药物维持麻醉的技术相比，那些结合使用区域麻醉和镇痛的麻醉技术似乎更有益。进一步的研究应有助于阐明肿瘤手术中麻醉过程的长期临床相关性。
