Tzoneva D, Cherkezov J, Georgiev S, Masljankov Sv, Todorov G
Khirurgiia (Sofiia). 2014(2):69-74.
The main treatment for most types of malignant tumors is their surgical removal. During the past years there has been a growing interest in the anesthesia effects on long-term surgery results in connection with cancer. Modern clinical and laboratory data indicate that the anesthetic technique may play a role in tumor dissemination and recurrence. The purpose of this study is to review the available literature data on the anesthetic techniques applied in oncology surgery, long-term consequences of anesthesia/analgesia and their relation to tumor progression.
We have reviewed the specialized medical literature and have analyzed the effects of anesthesia/analgesia on long-term results of surgical treatment--incidence of local recurrence, metastases and patients' survival.
The hypothesis about the influence of the anesthesia type on long-term results after cancer surgery is generated. The use of anesthetics and analgesics with low potential for immunosuppression may reduce the relapse. This is a useful approach for patients with cancer.
Further randomized controlled trials are required for extensive research of this problem.
大多数类型恶性肿瘤的主要治疗方法是手术切除。在过去几年中,人们越来越关注麻醉对癌症相关长期手术结果的影响。现代临床和实验室数据表明,麻醉技术可能在肿瘤播散和复发中起作用。本研究的目的是回顾肿瘤外科手术中应用的麻醉技术、麻醉/镇痛的长期后果及其与肿瘤进展关系的现有文献数据。
我们回顾了专业医学文献,并分析了麻醉/镇痛对手术治疗长期结果的影响——局部复发、转移的发生率以及患者生存率。
提出了关于麻醉类型对癌症手术后长期结果影响的假设。使用免疫抑制潜力低的麻醉剂和镇痛药可能会降低复发率。这对癌症患者是一种有用的方法。
需要进一步进行随机对照试验以广泛研究这个问题。