Obstetrics and Gynecology, Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy.
Fertil Steril. 2012 Jul;98(1):36-40. doi: 10.1016/j.fertnstert.2012.04.051. Epub 2012 May 31.
Endometriosis is a chronic inflammatory disease affecting women's health. Pain and infertility are the major symptoms caused by a hormonal/immunological dysfunction, which causes an endometrial impairment. The same pathogenetic mechanisms are also associated with preterm birth: hormones, cytokines, neurohormones, and growth factors interact in modulating extracellular matrix and prostaglandin secretion, thus activating the inflammatory process in placental membranes and myometrium. An overlap of molecules and mechanisms may explain the evidence that preterm birth is a common outcome in pregnant patients with endometriosis.
子宫内膜异位症是一种影响女性健康的慢性炎症性疾病。疼痛和不孕是由激素/免疫功能障碍引起的主要症状，这会导致子宫内膜损伤。同样的发病机制也与早产有关：激素、细胞因子、神经激素和生长因子相互作用，调节细胞外基质和前列腺素的分泌，从而激活胎盘膜和子宫平滑肌中的炎症过程。分子和机制的重叠可以解释这样一个证据，即患有子宫内膜异位症的孕妇早产是一种常见的结果。
