Department of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
Transl Res. 2012 Jul;160(1):65-83. doi: 10.1016/j.trsl.2011.12.002. Epub 2011 Dec 23.
Several studies have reported on the association between inflammatory bowel disease (IBD) and adverse pregnancy outcomes, such as preterm birth. The exact mechanisms of action are unclear; however, several pathways and processes are involved in both IBD and pregnancy that may help explain this. In this review, we discuss the immune system's T helper cells and human leukocyte antigens, inflammation, its function, and the role of Toll-like receptors (TLRs), NOD-like receptors (NLRs), and prostaglandins in the inflammatory response. For each of these topics, we consider their involvement in IBD and pregnancy, and we speculate as to how they can lead to preterm birth. Finally, we review briefly corticosteroids, biologic therapies, and immunosuppressants for the treatment of IBD, as well as their safety in use during pregnancy, with special focus on preterm birth.
几项研究报告了炎症性肠病（IBD）与不良妊娠结局之间的关联，例如早产。确切的作用机制尚不清楚；然而，IBD 和妊娠都涉及到几个途径和过程，这可能有助于解释这一点。在这篇综述中，我们讨论了免疫系统的辅助性 T 细胞和人类白细胞抗原、炎症及其功能，以及 Toll 样受体（TLRs）、NOD 样受体（NLRs）和前列腺素在炎症反应中的作用。对于这些主题中的每一个，我们都考虑了它们在 IBD 和妊娠中的参与，并推测它们如何导致早产。最后，我们简要回顾了皮质类固醇、生物疗法和免疫抑制剂治疗 IBD，以及它们在妊娠期间使用的安全性，特别关注早产。
