Département d'Informatique, Faculté des Sciences, Université de Sherbrooke, Canada.
Comput Med Imaging Graph. 2012 Sep;36(6):484-91. doi: 10.1016/j.compmedimag.2012.05.002. Epub 2012 Jun 2.
We introduce a new approach to extract the input function and the tissue time activity curve from dynamic ECG-gated (18)F-FDG PET images. These curves are mandatory to model the myocardium metabolic rate of glucose for heart studies. The proposed method utilizes coupled active contours to track the myocardium and the blood pool deformations. Furthermore, a statistical approach is developed to model the blood and tissue activities and to correct for spillovers. The developed algorithm offers a reliable alternative to serial blood sampling for small animal cardiac PET studies. Indeed, the calculated MMRG value differs by 1.54% only from the reference value.
我们介绍了一种从动态心电图门控（18）F-FDG PET 图像中提取输入函数和组织时间活动曲线的新方法。这些曲线对于为心脏研究建模心肌葡萄糖代谢率是必需的。所提出的方法利用耦合主动轮廓来跟踪心肌和血池的变形。此外，还开发了一种统计方法来建模血液和组织的活动，并进行溢出校正。该算法为小动物心脏 PET 研究中的连续血液采样提供了可靠的替代方法。实际上，计算出的 MMRG 值与参考值仅相差 1.54%。
