Kaplan C, Muller J Y, Doinel C, Lefrère J J, Paquez F, Rouger P, Salmon D, Salmon C
Institut National de Transfusion Sanguine, Paris, France.
Hum Hered. 1990;40(5):290-8. doi: 10.1159/000153947.
No difference in HLA-A, B or DR gene frequencies could be observed between 172 control subjects and 180 HIV-1-seropositive subjects of European ancestry diagnosed through the systematic screening of blood donations. In contrast, progression to acquired immune deficiency syndrome (AIDS; 21 patients) or CD4 lymphocyte loss equal or more than 20% over a 6-month period (37 subjects) was found to be associated with the B8DR3 haplotype (relative risk = 10.64, p less than 0.003, and 2.23, p less than 0.092, respectively). Other independently significant associations assessed through the multivariate Cox proportional-hazards model were B16, BW21 and B35 alleles as factors of bad prognosis. Conversely, A11 and DR4 alleles were factors favouring longer survival.
通过对献血者进行系统筛查诊断出的172名欧洲血统对照受试者和180名HIV-1血清阳性受试者之间，未观察到HLA-A、B或DR基因频率存在差异。相比之下，发现进展为获得性免疫缺陷综合征（艾滋病；21例患者）或在6个月内CD4淋巴细胞丢失等于或超过20%（37名受试者）与B8DR3单倍型相关（相对风险分别为10.64，p<0.003和2.23，p<0.092）。通过多变量Cox比例风险模型评估的其他独立显著关联是B16、BW21和B35等位基因作为不良预后因素。相反，A11和DR4等位基因是有利于更长生存期的因素。
