HLA与艾滋病易感性：HLA B35是意大利感染HIV的静脉吸毒者的主要危险因素。
HLA-associated susceptibility to AIDS: HLA B35 is a major risk factor for Italian HIV-infected intravenous drug addicts.
作者信息
Scorza Smeraldi R, Fabio G, Lazzarin A, Eisera N, Uberti Foppa C, Moroni M, Zanussi C
机构信息
Institute of Internal Medicine, Infectious Diseases and Immunopathology, University of Milan, Italy.
出版信息
Hum Immunol. 1988 Jun;22(2):73-9. doi: 10.1016/0198-8859(88)90038-9.
Thirty-one AIDS patients were typed for HLA A, B, C, and DR antigens. We confirmed that frequency of B35 is significantly higher in patients than in controls. No significant frequency differences in other HLA antigens were found. The analysis of HLA distribution in AIDS patients by risk categories suggests that B35 is a major risk factor, primarily mainly for patients belonging to the category of intravenous (IV) drug addicts.
对31名艾滋病患者进行了HLA A、B、C和DR抗原分型。我们证实，患者中B35的频率显著高于对照组。在其他HLA抗原方面未发现显著的频率差异。按风险类别对艾滋病患者的HLA分布进行分析表明，B35是一个主要风险因素，主要针对静脉注射吸毒者这一类别中的患者。
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