Department of Cardiovascular Sciences, University of Leicester, Leicester LE2 7LX, UK.
Eur J Vasc Endovasc Surg. 2012 Aug;44(2):127-32. doi: 10.1016/j.ejvs.2012.05.009. Epub 2012 May 31.
A recent GWAS demonstrated an association between low density lipoprotein receptor related protein 1 (LRP1) and abdominal aortic aneurysm (AAA). This review aims to identify how LRP1 may be involved in the pathogenesis of abdominal aortic aneurysm.
A systematic review of the English language literature was undertaken in order to determine whether LRP1 and associated pathways were plausible candidates for contributing to the development and/or progression of AAA.
A comprehensive literature search of MEDLINE (since 1948), Embase (since 1980) and Health and Psychological Instruments (since 1985) was conducted in January 2012 identified 50 relevant articles. These studies demonstrate that LRP1 has a diverse range of biological functions and is a plausible candidate for playing a central role in aneurysmogenesis. Importantly, LRP1 downregulates MMP (matrix metalloproteinase) activity in vascular smooth muscle cells and regulates other key pathways involved in extracellular matrix remodelling and vascular smooth muscle migration and proliferation. Crucially animal studies have shown that LRP1 depletion leads to progressive destruction of the vascular architecture and aneurysm formation.
Published evidence suggests that LRP1 may play a key role in the development of AAA.
最近的全基因组关联研究表明，低密度脂蛋白受体相关蛋白 1（LRP1）与腹主动脉瘤（AAA）之间存在关联。本综述旨在确定 LRP1 如何参与腹主动脉瘤的发病机制。
系统检索了英语文献，以确定 LRP1 及其相关途径是否有可能成为导致 AAA 发生和/或进展的候选因素。
2012 年 1 月对 MEDLINE（自 1948 年以来）、Embase（自 1980 年以来）和健康与心理仪器（自 1985 年以来）进行了全面的文献检索，共确定了 50 篇相关文章。这些研究表明，LRP1 具有广泛的生物学功能，是在动脉瘤形成中发挥核心作用的合理候选者。重要的是，LRP1 下调血管平滑肌细胞中 MMP（基质金属蛋白酶）的活性，并调节其他参与细胞外基质重塑以及血管平滑肌迁移和增殖的关键途径。至关重要的是，动物研究表明，LRP1 的耗竭会导致血管结构的进行性破坏和动脉瘤的形成。
已发表的证据表明，LRP1 可能在 AAA 的发生发展中起关键作用。
