Department of Cardiology, Zhejiang Hospital, Hangzhou, Zhejiang, China.
Department of Medicine, the Second College of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, China.
Vascular. 2023 Jun;31(3):417-432. doi: 10.1177/17085381221077502. Epub 2022 Mar 14.
Abdominal aortic aneurysm (AAA) is a deadly disease in the elderly population. Currently, the association between single nucleotide polymorphisms (SNPs) and the presence of AAAs has become a hot topic and is a concern for many researchers.
We performed a document retrieval in PubMed, EMBASE, and the Cochrane Library (to January 2020). A total of 17 case-control reports on SNPs of AAAs and eight SNPs of correlation factors were selected. All essential data, including race, age, country, criteria of AAA diagnosis, method of AAA measurement, method of genotype detection, name of SNPs, minor allele frequency (MAF), Hardy Weinberg equilibrium (HWE) of the control group, and number of cases and control groups were extracted by two reviewers independently. The fixed-effect model and random-effect model were used to calculate the overall odds ratios (ORs) and 95% confidence intervals (CIs). The association between selected SNPs and the presence of AAAs was evaluated under different genetic models (dominant, codominant, recessive, overdominant, and allele models).
A total of 17 articles (sample size ranging from to 42-665 AAA cases and 49-2,297 controls) and 23 SNPs of related factors were identified. Eight SNPs were assessed in at least two studies and were selected for further meta-analysis. We found that the A allele of interleukin (IL)-10 (-1082 G/A) (OR: 1.35, 95% CI: 1.18-1.54, < 0.0001) was a risk factor for AAAs under random and fixed-effect models. In addition, partial genetic models of these SNPs were confirmed to be related to the presence of AAA. Subgroup analysis revealed that haptoglobin (HP)-1 was a risk factor for AAAs (OR: 1.30, 95% CI: 1.04-1.63, = 0.02) in the European population. No association was found between the occurrence of AAA and the other SNPs.
In our current meta-analysis, we speculated that the genotype distribution of IL-10 (-1082 G/A) may be associated with the emergence of AAA.
腹主动脉瘤（AAA）是老年人群中的一种致命性疾病。目前，单核苷酸多态性（SNP）与 AAA 发生之间的关联已成为热门话题，引起了许多研究人员的关注。
我们在 PubMed、EMBASE 和 Cochrane Library （截至 2020 年 1 月）中进行了文献检索。共选择了 17 项关于 AAA 相关 SNP 和 8 项相关因素 SNP 的病例对照报告。所有重要数据，包括种族、年龄、国家、AAA 诊断标准、AAA 测量方法、基因型检测方法、SNP 名称、次要等位基因频率（MAF）、对照组 Hardy-Weinberg 平衡（HWE）以及病例和对照组的数量，均由两名评审员独立提取。采用固定效应模型和随机效应模型计算总的比值比（OR）和 95%置信区间（CI）。在不同的遗传模型（显性、共显性、隐性、超显性和等位基因模型）下，评估了所选 SNP 与 AAA 发生之间的关系。
共纳入 17 篇文献（AAA 病例数范围为 42-665，对照组为 49-2297）和 23 个相关因素的 SNP。其中 8 个 SNP 在至少 2 项研究中进行了评估，并进一步进行了荟萃分析。我们发现白细胞介素（IL）-10（-1082 G/A）的 A 等位基因（OR：1.35，95%CI：1.18-1.54，<0.0001）在随机和固定效应模型下是 AAA 的危险因素。此外，这些 SNP 的部分遗传模型被证实与 AAA 的发生有关。亚组分析显示，结合珠蛋白（HP）-1 是欧洲人群 AAA 的危险因素（OR：1.30，95%CI：1.04-1.63，=0.02）。未发现其他 SNP 与 AAA 的发生有关。
在我们目前的荟萃分析中，我们推测 IL-10（-1082 G/A）的基因型分布可能与 AAA 的发生有关。
