γ-谷氨酰转移酶、丙氨酸转氨酶和天门冬氨酸转氨酶水平与妊娠期糖尿病的诊断。
Gamma-glutamyltransferase, alanine transaminase and aspartate transaminase levels and the diagnosis of gestational diabetes mellitus.
机构信息
Department of Obstetrics & Gynecology, University of Malaya, Lembah Pantai, Kuala Lumpur 50603, Malaysia.
出版信息
Clin Biochem. 2012 Oct;45(15):1192-6. doi: 10.1016/j.clinbiochem.2012.05.025. Epub 2012 May 31.
OBJECTIVES
To evaluate gamma-glutamyltransferase (GGT), alanine transaminases (ALT) and aspartate transaminases (AST) levels and prevalent gestational diabetes mellitus (GDM).
DESIGN AND METHODS
Random plasma glucose, GGT, ALT and AST and the 50-g glucose challenge test were done on antenatal women followed by diagnostic 3-point 75-g oral glucose tolerance test within two weeks. GDM was diagnosed by ADA (2011) criteria.
RESULTS
The GDM rate was 12.2% (319/2610). Mean GGT level was higher in GDM women, 18 ± 12 vs. 16 ± 11 IU/L; P=0.03. The risk for GDM was higher for women in the highest GGT quartile band compared to the lowest: RR 1.35 95%CI 1.0-1.8; P=0.04. However, after adjustment for confounders, GGT was no longer associated with GDM. There was no correlation between ALT and AST levels and GDM.
CONCLUSIONS
Liver transaminases do not predict GDM in contrast to type 2 diabetes.
目的
评估γ-谷氨酰转移酶（GGT）、丙氨酸转氨酶（ALT）和天冬氨酸转氨酶（AST）水平与妊娠糖尿病（GDM）的相关性。
设计和方法
对进行产前检查的女性进行随机血浆葡萄糖、GGT、ALT 和 AST 检测以及 50g 葡萄糖负荷试验，两周内进行诊断性 3 点 75g 口服葡萄糖耐量试验。GDM 的诊断采用 ADA（2011）标准。
结果
GDM 的发生率为 12.2%（319/2610）。GDM 女性的平均 GGT 水平更高，为 18±12IU/L，而正常血糖孕妇的 GGT 水平为 16±11IU/L；P=0.03。与 GGT 最低四分位组相比，GGT 最高四分位组女性发生 GDM 的风险更高：RR 1.35，95%CI 1.0-1.8；P=0.04。然而，经过混杂因素调整后，GGT 与 GDM 不再相关。ALT 和 AST 水平与 GDM 之间无相关性。
结论
与 2 型糖尿病不同，肝转氨酶不能预测 GDM。
Zotero 插件