Tan Peng C, Mubarak Sarah, Omar Siti Z
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Malaya, Lembah Pantai, Kuala Lumpur, Malaysia.
J Obstet Gynaecol Res. 2008 Aug;34(4):512-7. doi: 10.1111/j.1447-0756.2008.00815.x.
To evaluate the relationship between gamma-glutamyltransferase (GGT) level in pregnant women at oral glucose tolerance test (OGTT) and the diagnosis of gestational diabetes (GDM).
Blood was taken for analyzing GGT level from women at high risk of GDM at the time of their scheduled OGTT. GDM was diagnosed according to World Health Organization 1999 criteria.
GGT level correlated positively with the 2-hour glucose level (Spearman's rho = 0.112: P < 0.05). GGT values that were stratified into quartiles demonstrated a significant trend with diagnosis of GDM (chi(2) for trend; P = 0.03). Multivariable logistic regression analysis taking into account maternal age, gestational age at OGTT, body mass index and a positive 50-g glucose challenge test (GCT) indicated that high GGT was an independent risk factor for GDM (adjusted odds ratio [AOR] 2.1 95% CI 1.2-3.8: P = 0.01). In the subset of women identified by a positive GCT, on multivariable logistic regression analysis, only high GGT was an independent risk factor for GDM (AOR 2.3 95% CI 1.3-4.2: P = 0.007).
Raised GGT level is an independent risk factor for GDM in high risk pregnant women undergoing OGTT.
评估口服葡萄糖耐量试验（OGTT）时孕妇γ-谷氨酰转移酶（GGT）水平与妊娠期糖尿病（GDM）诊断之间的关系。
在预定进行OGTT时，采集有GDM高危风险女性的血液以分析GGT水平。根据世界卫生组织1999年标准诊断GDM。
GGT水平与2小时血糖水平呈正相关（Spearman秩相关系数=0.112，P<0.05）。将GGT值分层为四分位数显示与GDM诊断有显著趋势（趋势χ²检验，P=0.03）。多变量逻辑回归分析考虑了孕妇年龄、OGTT时的孕周、体重指数和50克葡萄糖筛查试验（GCT）阳性，结果表明高GGT是GDM的独立危险因素（调整优势比[AOR]2.1，95%可信区间1.2 - 3.8，P=0.01）。在GCT阳性的女性亚组中，多变量逻辑回归分析显示，只有高GGT是GDM的独立危险因素（AOR 2.3，95%可信区间1.3 - 4.2，P=0.007）。
对于接受OGTT的高危孕妇，GGT水平升高是GDM的独立危险因素。
