Department of Family Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.
J Nutr Health Aging. 2012;16(6):520-4. doi: 10.1007/s12603-011-0344-6.
Metabolic syndrome (MetS) was common in the elderly, but its prognostic significance in older old population remained unclear. The main purpose of this study was to evaluate the survival impact of MetS among older men aged 75 and over in Taiwan.
From 2008, residents aged 75 years and older of Banciao Veterans Home were invited for study and were followed for 3 years. All participants received history taking, physical examinations, and laboratory tests. Mortality was determined by Veteran Affairs Death Registry, which was linked to the National Death Registry.
Overall, 680 men (mean age: 82.5±4.7 years) were enrolled for study and the prevalence of MetS was 31.6%. During the follow-up period, 140 (20.6%) participants died, and the causes of death included infectious diseases (62, 9.1%), cardiovascular disease (37, 5.4%), cancer (20, 2.9%), and others (21, 3.1%). MetS subjects had a significantly higher prevalence of hypertension, diabetes mellitus, and having higher body mass index, waist circumferences, systolic blood pressure, fasting blood glucose, serum triglyceride and lower HDL-C level than non-MetS subjects. However, MetS subjects were less likely to die during study period (16.3% vs. 22.6%, P=0.059). Multivariate logistic regression showed that older age (OR:1.04, 95% C.I.: 1.00-1.08, P=0.04), diabetes mellitus (OR: 2.10, 95% CI: 1.34-3.30, P=0.001) were independent risk factors for mortality; and serum total cholesterol and triglyceride were protective factors (OR: 0.99, 95% CI: 0.99-1.00, P=0.037 for cholesterol; OR: 0.99, 95% CI: 0.99-1.00, P=0.013 for triglyceride). Adjusted for age, diabetes mellitus, serum levels of total cholesterol, and triglyceride, MetS played a potential trend of survival benefits among study subjects (HR: 0.71, 95% CI: 0.45-1.12, P=0.144).
The prevalence of MetS among men aged 75 years and over was 31.6%, and the 3-year mortality rate was 20.6%. Older age, diabetes mellitus, lower serum cholesterol and lower serum triglyceride were independent risk factors for mortality. Further investigation is needed to clarify the prognostic impact of MetS in older adults.
代谢综合征（MetS）在老年人中很常见，但在高龄人群中的预后意义尚不清楚。本研究的主要目的是评估台湾 75 岁及以上高龄男性代谢综合征对生存的影响。
从 2008 年起，邀请板桥荣民之家 75 岁及以上的居民参加研究，并随访 3 年。所有参与者均接受病史询问、体格检查和实验室检查。通过退伍军人事务部死亡登记处确定死亡率，该登记处与国家死亡登记处相关联。
共有 680 名男性（平均年龄：82.5±4.7 岁）被纳入研究，代谢综合征的患病率为 31.6%。在随访期间，有 140 名（20.6%）参与者死亡，死因包括传染病（62 例，9.1%）、心血管疾病（37 例，5.4%）、癌症（20 例，2.9%）和其他（21 例，3.1%）。代谢综合征患者的高血压、糖尿病患病率以及体重指数、腰围、收缩压、空腹血糖、血清甘油三酯水平较高，高密度脂蛋白胆固醇水平较低，而非代谢综合征患者则更高。然而，在研究期间，代谢综合征患者的死亡率较低（16.3%比 22.6%，P=0.059）。多变量 logistic 回归显示，年龄较大（OR：1.04，95%CI：1.00-1.08，P=0.04）、糖尿病（OR：2.10，95%CI：1.34-3.30，P=0.001）是死亡的独立危险因素；而血清总胆固醇和甘油三酯是保护因素（OR：0.99，95%CI：0.99-1.00，P=0.037 用于胆固醇；OR：0.99，95%CI：0.99-1.00，P=0.013 用于甘油三酯）。调整年龄、糖尿病、血清总胆固醇和甘油三酯水平后，代谢综合征在研究对象中具有潜在的生存获益趋势（HR：0.71，95%CI：0.45-1.12，P=0.144）。
75 岁及以上男性代谢综合征的患病率为 31.6%，3 年死亡率为 20.6%。年龄较大、糖尿病、血清胆固醇和甘油三酯水平较低是死亡的独立危险因素。需要进一步研究来阐明代谢综合征对老年人的预后影响。
