Bijani Ali, Hosseini Seyed Reza, Ghadimi Reza, Mouodi Simin
Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
Int J Endocrinol Metab. 2020 Jan 28;18(1):e91837. doi: 10.5812/ijem.91837. eCollection 2020 Jan.
Metabolic syndrome (MetS) as an important risk factor arising from insulin resistance accompanying abnormal adipose deposition and function has become a major challenge to public health around the world.
This research was conducted to evaluate the association of MetS and its components with survival of older adults.
This prospective study is a part of the Amirkola Health and Ageing Cohort Project (2011 - 2017) conducted among 1562 older adults (aged 60 years and over) living in Amirkola, north of Iran. MetS was defined according to four sets of definition: Iranian definition, International Diabetes Federation (IDF) definition, 2001 Adult Treatment Panel (ATP) III and 2005 Adult Treatment Panel (ATP) III.
Eight hundred sixty-three (55.2%) males and 699 (44.8%) females with a mean age of 69.3 ± 7.4 years were included in the research. The results showed that 71.9%, 74.3%, 68.8% and 66.7% of older adults had MetS based on 2005 ATP III, Iranian, IDF and 2001 ATP III diagnostic criteria, respectively. Only raised fasting plasma glucose (FPG) had a significant association with a five-year survival rate of older adults (FPG ≥ 110mg/dL: adjusted HR: 2.05; 95% CI: 1.51 - 2.78; P < 0.001). Other MetS components did not show any significant associations with survival (P > 0.05). Nevertheless, MetS itself significantly decreased the survival rate of older adults after adjusting age, gender and number of chronic diseases (HR = 1.67; 95% CI: 1.16 - 2.41; P = 0.006).
MetS and one of its components, high FPG, have significant associations with survival of older adults.
代谢综合征（MetS）作为一种由胰岛素抵抗伴异常脂肪沉积和功能引发的重要危险因素，已成为全球公共卫生面临的重大挑战。
本研究旨在评估代谢综合征及其组分与老年人存活率之间的关联。
这项前瞻性研究是阿米尔科拉健康与老龄化队列项目（2011 - 2017年）的一部分，该项目在伊朗北部阿米尔科拉的1562名老年人（年龄60岁及以上）中开展。代谢综合征根据四套定义来界定：伊朗定义、国际糖尿病联盟（IDF）定义、2001年成人治疗小组（ATP）III以及2005年成人治疗小组（ATP）III。
研究纳入了863名（55.2%）男性和699名（44.8%）女性，平均年龄为69.3±7.4岁。结果显示，分别依据2005年ATP III、伊朗、IDF和2001年ATP III诊断标准，71.9%、74.3%、68.8%和66.7%的老年人患有代谢综合征。仅空腹血糖（FPG）升高与老年人的五年存活率存在显著关联（FPG≥110mg/dL：校正后风险比[HR]：2.05；95%置信区间[CI]：1.51 - 2.78；P<0.001）。其他代谢综合征组分与存活率未显示出任何显著关联（P>0.05）。然而经年龄、性别和慢性病数量校正后，代谢综合征本身显著降低了老年人的存活率（HR = 1.67；95% CI：1.16 - 2.41；P = 0.006）。
代谢综合征及其组分之一，即高FPG，与老年人的存活率存在显著关联。
