Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, CIHIDECAR, CONICET, 1428 Buenos Aires, Argentina.
Nano Lett. 2012 Jul 11;12(7):3537-44. doi: 10.1021/nl301093s. Epub 2012 Jun 4.
Photoswitchable semiconductor nanoparticles, quantum dots (QDs), couple the advantages of conventional QDs with the ability to reversibly modulate the QD emission, thereby improving signal detection by rejection of background signals. Using a simple coating methodology with polymers incorporating a diheteroarylethene photochromic FRET acceptor as well as a spectrally distinct organic fluorophore, photoswitchable QDs were prepared that are small, biocompatible, and feature ratiometric dual emission. With programmed irradiation, the fluorescence intensity ratio can be modified by up to ∼100%.
光致变色半导体纳米粒子，即量子点（QDs），结合了传统 QDs 的优势以及可逆调制 QD 发射的能力，从而通过消除背景信号提高了信号检测的灵敏度。通过使用一种简单的聚合物涂层方法，将包含二芳基乙烯光致变色荧光能量转移受体以及光谱明显不同的有机荧光团的聚合物结合在一起，制备了具有小型、生物相容性和比率双发射特性的光致变色 QDs。通过编程照射，可以将荧光强度比最多修改约 100%。
