Epidemic Intelligence Service, Career Development Division, Office of Workforce and Career Development, National Center for Chronic Disease Prevention and Health Promotion, CDC, Atlanta, Georgia 30341, USA.
J Womens Health (Larchmt). 2012 Aug;21(8):865-71. doi: 10.1089/jwh.2012.3487. Epub 2012 Jun 4.
The objective of this study was to assess the relationship between body mass index (BMI) and epithelial ovarian cancer survival among young women.
We conducted a cohort analysis of 425 women aged 20-54 years with incident epithelial ovarian cancer enrolled during 1980-1982 in Cancer and Steroid Hormone (CASH), a population-based, case-control study. Participants' vital status was ascertained though linkage with the Surveillance, Epidemiology and End Results (SEER) program. Using Cox proportional hazards models, we estimated adjusted hazard ratios (HR) and 95% confidence intervals (CI) for the association between survival and usual adult BMI, BMI at age 18, and weight change from age 18 to adult.
During a follow-up of up to 17 years, 215 women died. Compared to women with an adult BMI in the lowest quartile (<20.7), women in the second (20.8-22.5), third (22.6-24.9), and fourth (≥25.0) quartiles were not at increased risk for death (HR 1.2, 95% CI 0.8-1.8; HR 1.1, 95% CI 0.7-1.6; and HR 0.9, 95% CI 0.6-1.4, respectively) (p trend=0.6). Similarly, neither age 18 BMI nor weight change were associated with ovarian cancer survival.
Although elevated BMI is associated with increased ovarian cancer risk among young women, we found no evidence of its association with ovarian cancer survival in this population.
本研究旨在评估体重指数（BMI）与年轻女性上皮性卵巢癌生存之间的关系。
我们对 1980-1982 年期间参加基于人群的病例对照研究癌症和类固醇激素（CASH）的 425 名 20-54 岁的上皮性卵巢癌女性患者进行了队列分析。通过与监测、流行病学和最终结果（SEER）计划的联系来确定参与者的生存状态。使用 Cox 比例风险模型，我们估计了生存与成年期常用 BMI、18 岁时 BMI 和从 18 岁到成年体重变化之间的关联的调整后的风险比（HR）和 95%置信区间（CI）。
在长达 17 年的随访中，有 215 名女性死亡。与成年 BMI 处于最低四分位数（<20.7）的女性相比，第二（20.8-22.5）、第三（22.6-24.9）和第四（≥25.0）四分位数的女性死亡风险并未增加（HR 1.2，95%CI 0.8-1.8；HR 1.1，95%CI 0.7-1.6；HR 0.9，95%CI 0.6-1.4，分别）（p 趋势=0.6）。同样，18 岁时 BMI 和体重变化均与卵巢癌生存无关。
尽管 BMI 升高与年轻女性卵巢癌风险增加有关，但我们在该人群中未发现 BMI 与卵巢癌生存之间存在关联的证据。
