Choy A M, Lang C C
Department of Surgery, Ninewells Hospital, Medical School, Dundee, Scotland, UK.
J Intern Med. 1990 Oct;228(4):409-10. doi: 10.1111/j.1365-2796.1990.tb00254.x.
A 65-year-old man on maintenance dapsone therapy for dermatitis herpetiformis for 30 years was admitted to hospital with acute abdominal pain and vomiting. Investigations revealed a Heinz body haemolytic anaemia. Worsening symptoms prompted an emergency laparotomy that revealed a perforated gall bladder with pigmented biliary calculi. In previous reviews of the haematological abnormalities associated with dapsone therapy, life-threatening cholecystitis has not been described.
