HEPSIN 基因的变异与前列腺癌的易感性有关。
Variants in the HEPSIN gene are associated with susceptibility to prostate cancer.
机构信息
Advanced Urogenital Disease Research Center, Chung-Ang University College of Medicine, Seoul, Korea.
出版信息
Prostate Cancer Prostatic Dis. 2012 Dec;15(4):353-8. doi: 10.1038/pcan.2012.17. Epub 2012 Jun 5.
BACKGROUND
HEPSIN (HPN) gene is one of the most consistently overexpressed genes in patients with prostate cancer; furthermore, there is some evidence supporting an association between HPN gene variants and the risk of developing prostate cancer. In this study, sequence variants in the HPN gene were investigated to determine whether they were associated with prostate cancer risk in a Korean study cohort.
METHODS
We evaluated the association of 17 single-nucleotide polymorphisms (SNPs) in the HPN gene with prostate cancer risk and clinical characteristics (Gleason score and tumor stage) in Korean men (240 case subjects and 223 control subjects) using unconditional logistic regression.
RESULTS
The statistical analysis suggested that three SNPs (rs45512696, rs2305745, rs2305747) were significantly associated with the risk of prostate cancer (odds ratio (OR)=2.22, P=0.04; OR=0.73, P=0.03; OR=0.76, P=0.05, respectively).
CONCLUSIONS
The results of this study suggest that, in Korean men, some polymorphisms in the HPN gene might be associated with the risk of developing prostate cancer.
背景
HEPSIN（HPN）基因是前列腺癌患者中最常过度表达的基因之一；此外，有一些证据支持 HPN 基因变异与前列腺癌风险之间存在关联。在这项研究中，研究了 HPN 基因中的序列变异，以确定它们是否与韩国研究队列中的前列腺癌风险相关。
方法
我们使用无条件逻辑回归评估了 HPN 基因中的 17 个单核苷酸多态性（SNP）与韩国男性（240 例病例和 223 例对照）前列腺癌风险和临床特征（Gleason 评分和肿瘤分期）的关联。
结果
统计分析表明，三个 SNP（rs45512696、rs2305745、rs2305747）与前列腺癌风险显著相关（比值比（OR）=2.22，P=0.04；OR=0.73，P=0.03；OR=0.76，P=0.05）。
结论
本研究结果表明，在韩国男性中，HPN 基因的一些多态性可能与前列腺癌的发病风险相关。
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