Advanced Urogenital Disease Research Center, Chung-Ang University College of Medicine, Seoul, South Korea.
World J Urol. 2012 Apr;30(2):225-32. doi: 10.1007/s00345-011-0690-3. Epub 2011 May 7.
Chronic inflammation has been considered a potential risk factor for prostate cancer. Toll-like receptors (TLRs) are important in the innate immune response to pathogens and in cross talk between innate immunity and adaptive immunity. In this study, sequence variants in the TLR4 gene were investigated to determine whether they were associated with prostate cancer risk in a Korean cohort.
An association study between 11 single-nucleotide polymorphisms (SNPs) of the TLR4 gene and prostate cancer was performed in 463 Korean male subjects including 240 prostate cancer patients and 223 healthy controls. SNPs were genotyped using the TaqMan assay, and their association with the risk of prostate cancer was evaluated using logistic regression analysis.
The statistical analysis revealed that one SNP at the 3'UTR (rs11536889) showed significant association with the risk of prostate cancer (P (corr) = 0.005, OR = 1.81). One common haplotype (ht2) was also significantly associated with the risk of prostate cancer (P (corr) = 0.009, OR = 1.77). However, further analysis showed no association between any of the SNPs and prostate cancer prognostic factors such as the Gleason score or tumor stage.
The findings of this study suggest that polymorphisms of the TLR4 gene might be associated with the risk of prostate cancer in Korean men.
慢性炎症被认为是前列腺癌的一个潜在风险因素。 Toll 样受体 (TLR) 在病原体的固有免疫反应以及固有免疫与适应性免疫的相互作用中起着重要作用。在这项研究中，研究了 TLR4 基因中的序列变异，以确定它们是否与韩国队列中的前列腺癌风险相关。
在包括 240 名前列腺癌患者和 223 名健康对照的 463 名韩国男性受试者中，进行了 TLR4 基因 11 个单核苷酸多态性 (SNP) 与前列腺癌的关联研究。使用 TaqMan 测定法对 SNP 进行基因分型，并使用逻辑回归分析评估其与前列腺癌风险的关联。
统计分析显示，3'UTR 中的一个 SNP(rs11536889)与前列腺癌的风险显著相关(P(corr)=0.005，OR=1.81)。一个常见的单倍型(ht2)也与前列腺癌的风险显著相关(P(corr)=0.009，OR=1.77)。然而，进一步的分析表明，任何 SNP 与前列腺癌的预后因素（如 Gleason 评分或肿瘤分期）之间均无关联。
本研究的结果表明，TLR4 基因的多态性可能与韩国男性前列腺癌的风险相关。
