Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea.
Yonsei Med J. 2012 Jul 1;53(4):759-64. doi: 10.3349/ymj.2012.53.4.759.
We aimed to determine the prevalence of anti-cyclic citrullinated peptide (anti-CCP) antibodies in a large group of Korean patients with Behçet's disease (BD), with and without joint involvement, and to compare these findings with the prevalences of anti-CCP antibodies in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE).
We tested 189 patients with BD, 105 with RA, and 36 with SLE for anti-CCP antibodies and IgM rheumatoid factor in serum. We reviewed the medical records of patients with BD to investigate their personal and clinical characteristics as well as their laboratory test results.
Anti-CCP antibodies were detected in seven of the 189 BD patients (3.7%), at a mean titer of 30.6±44.4 U/mL, in 86 of the 105 RA patients (81.9%) with a mean titer of 198.8±205.7 U/mL, and in nine of the 36 SLE patients (25%) with a mean titer of 180.4±113.9 U/mL. One of the seven anti-CCP-positive BD patients fulfilled the diagnostic criteria for both BD and RA. Five of the seven anti-CCP-positive BD patients (71.4%) had polyarticular joint involvement, and the other two patients (28.6%) had oligoarticular involvement.
We determined the prevalence of anti-CCP antibodies in a large group of Korean BD patients with and without joint involvement. Negative anti-CCP test in patients with BD may help to differentiate BD from RA and SLE, all of which present with similar clinical features.
我们旨在确定大量韩国贝赫切特病（BD）患者，包括伴或不伴关节受累患者，抗环瓜氨酸肽（抗-CCP）抗体的流行率，并将这些发现与类风湿关节炎（RA）和系统性红斑狼疮（SLE）患者抗-CCP 抗体的流行率进行比较。
我们检测了 189 例 BD 患者、105 例 RA 患者和 36 例 SLE 患者血清中的抗-CCP 抗体和 IgM 类风湿因子。我们查阅了 BD 患者的病历，以调查其个人和临床特征以及实验室检查结果。
在 189 例 BD 患者中有 7 例（3.7%）检测到抗-CCP 抗体，平均滴度为 30.6±44.4 U/mL；在 105 例 RA 患者中有 86 例（81.9%）检测到抗-CCP 抗体，平均滴度为 198.8±205.7 U/mL；在 36 例 SLE 患者中有 9 例（25%）检测到抗-CCP 抗体，平均滴度为 180.4±113.9 U/mL。7 例抗-CCP 阳性 BD 患者中有 1 例符合 BD 和 RA 的双重诊断标准。7 例抗-CCP 阳性 BD 患者中有 5 例（71.4%）有多关节受累，另 2 例（28.6%）有少关节受累。
我们确定了大量韩国伴或不伴关节受累的 BD 患者抗-CCP 抗体的流行率。BD 患者抗-CCP 检测阴性可能有助于将 BD 与 RA 和 SLE 相鉴别，因为它们均具有相似的临床特征。
