Koca Suleyman Serdar, Akbulut Handan, Dag Sait, Artas Hakan, Isik Ahmet
Department of Rheumatology, Firat University, Faculty of Medicine, Elazig, Turkey.
Tohoku J Exp Med. 2007 Dec;213(4):297-304. doi: 10.1620/tjem.213.297.
Rheumatoid arthritis (RA) is associated with progressive joint destruction and disability. Early diagnosis of RA is important, since early and aggressive treatments lead to a better outcome. Circulating autoantibodies are a serological hallmark of systemic rheumatic diseases. More recently, antibodies directed to a cyclic citrullinated peptide, anti-CCP antibodies, have been established as specific diagnostic and prognostic tools for RA. The aims of this study were to assess the diagnostic and radiological prognostic value of the anti-CCP antibody in Turkish patients with RA (n = 97) and those with Behçet's disease (BD) (n = 46). The study also included 35 healthy controls. Anti-CCP antibodies were measured by ELISA, and radiological damage was evaluated by using modified Larsen scoring. In the RA group, sensitivity and specificity were 80.4% and 93.5% for rheumatoid factor (RF), and 74.2% and 97.8% for anti-CCP antibody, respectively. RF was positive in 3 BD patients (6.5%) and in one of the controls (2.9%). In contrast, anti-CCP antibodies were detected in one BD patient (2.2%), but not in the control subjects. Deformed joint counts and radiographic scores were higher in anti-CCP antibody-positive RA patients (n = 72) than those in anti-CCP antibody-negative patients (n = 25) (p < 0.05). Moreover, anti-CCP antibody titer correlated with deformed joint count (r = 0.224, p < 0.05) and radiographic score (r = 0.308, p < 0.05). This study indicates the diagnostic and prognostic utility of anti-CCP antibodies in Turkish patients with RA. Importantly, anti-CCP antibodies are not associated with BD.
类风湿关节炎（RA）与进行性关节破坏和残疾相关。RA的早期诊断很重要，因为早期积极治疗可带来更好的预后。循环自身抗体是系统性风湿性疾病的血清学标志。最近，针对环瓜氨酸肽的抗体，即抗CCP抗体，已被确立为RA的特异性诊断和预后工具。本研究的目的是评估抗CCP抗体在土耳其RA患者（n = 97）和白塞病（BD）患者（n = 46）中的诊断和放射学预后价值。该研究还纳入了35名健康对照者。通过酶联免疫吸附测定（ELISA）检测抗CCP抗体，并使用改良的 Larsen 评分评估放射学损伤。在RA组中，类风湿因子（RF）的敏感性和特异性分别为80.4%和93.5%，抗CCP抗体的敏感性和特异性分别为74.2%和97.8%。3名BD患者（6.5%）和1名对照者（2.9%）的RF呈阳性。相比之下，1名BD患者（2.2%）检测到抗CCP抗体，但对照者中未检测到。抗CCP抗体阳性的RA患者（n = 72）的关节畸形计数和放射学评分高于抗CCP抗体阴性患者（n = 25）（p < 0.05）。此外，抗CCP抗体滴度与关节畸形计数（r = 0.224，p < 0.05）和放射学评分（r = 0.308，p < 0.05）相关。本研究表明抗CCP抗体在土耳其RA患者中具有诊断和预后效用。重要的是，抗CCP抗体与BD无关。
