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维持性血液透析期间发现的肺鳞状细胞癌,经顺铂联合化疗后肿瘤缩小

[Squamous cell carcinoma of the lung detected during maintenance hemodialysis which reduced in size after combined CDDP chemotherapy].

作者信息

Umeki S, Wakunami M, Kawane H, Soegima R

机构信息

Department of Medicine, Kawasaki Medical School.

出版信息

Nihon Kyobu Shikkan Gakkai Zasshi. 1990 Sep;28(9):1225-9.

PMID:2266629
Abstract

A 52-year-old man receiving maintenance hemodialysis for 6 years was referred to our division for further evaluation and additional therapy for cough and hemosputum lasting 2 months, and for examination of a chest roentgenographic abnormality. Transbronchial lung biopsy specimens revealed squamous cell carcinoma of the lung. A total of 8 courses of anticancer chemotherapy with 25-30 mg/m2 of CDDP performed biweekly resulted in a partial remission (56%) but no side effects, including gastrointestinal damage and agranulocytosis. Few cases of lung cancer receiving anticancer chemotherapy with CDDP during maintenance hemodialysis have been reported. Administration methods and dosage of CDDP for patients receiving maintenance hemodialysis were discussed.

摘要

一名接受维持性血液透析6年的52岁男性因持续2个月的咳嗽和咯血前来我科进一步评估并接受额外治疗,同时检查胸部X线异常。经支气管肺活检标本显示为肺鳞状细胞癌。每两周进行一次共8个疗程的抗癌化疗,顺铂剂量为25 - 30mg/m²,结果达到部分缓解(56%),且无包括胃肠道损伤和粒细胞缺乏症在内的副作用。据报道,维持性血液透析期间接受顺铂抗癌化疗的肺癌病例很少。讨论了维持性血液透析患者顺铂的给药方法和剂量。

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