Wootla Bharath, Eriguchi Makoto, Rodriguez Moses
Departments of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
Autoimmune Dis. 2012;2012:969657. doi: 10.1155/2012/969657. Epub 2012 May 16.
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) with varied clinical presentations and heterogeneous histopathological features. The underlying immunological abnormalities in MS lead to various neurological and autoimmune manifestations. There is strong evidence that MS is, at least in part, an immune-mediated disease. There is less evidence that MS is a classical autoimmune disease, even though many authors state this in the description of the disease. We show the evidence that both supports and refutes the autoimmune hypothesis. In addition, we present an alternate hypothesis based on virus infection to explain the pathogenesis of MS.
多发性硬化症（MS）是一种中枢神经系统（CNS）的炎性脱髓鞘疾病，临床表现多样，组织病理学特征各异。MS潜在的免疫异常会导致各种神经和自身免疫表现。有充分证据表明，MS至少部分是一种免疫介导的疾病。尽管许多作者在疾病描述中称MS是经典的自身免疫性疾病，但支持这一观点的证据较少。我们展示了支持和反驳自身免疫假说的证据。此外，我们提出了一种基于病毒感染的替代假说，以解释MS的发病机制。
