Durnova G N, Kaplanskiĭ A S, Il'ina-Kakueva E I, Sakharova Z F
Kosm Biol Aviakosm Med. 1990 Sep-Oct;24(5):42-5.
Tibia and lumbar vertebrae of rats sacrificed 2 days after their 13-day space flight on Cosmos-1887 were examined histomorphometrically. It was found that the exposure led to osteoporosis of the primary and secondary spongiosa of tibia proximal metaphyses and early signs of bone reduction in the lumbar vertebrae spongiosa. The major cause of osteoporosis was inhibition of bone neoformation which was indicated by a lower number and activity of osteoblasts. A certain contribution was also made by enhanced bone resorption which was proven by a greater number of osteoclasts per bone volume and area unit in the tibia primary spongiosa. The fact that the rats were exposed to 1 G for 48 hours after landing resulted in readaptation developments, which were pointed to by a decrease of acid phosphatase in osteoclasts.
对在“宇宙-1887”号上进行了13天太空飞行后2天处死的大鼠的胫骨和腰椎进行了组织形态计量学检查。发现这种暴露导致胫骨近端干骺端初级和次级松质骨骨质疏松，以及腰椎松质骨骨量减少的早期迹象。骨质疏松的主要原因是骨形成的抑制，这表现为成骨细胞数量减少和活性降低。骨吸收增强也有一定作用，这在胫骨初级松质骨中每骨体积和面积单位破骨细胞数量增加得到证实。大鼠着陆后暴露于1G环境48小时这一事实导致了再适应过程，破骨细胞中酸性磷酸酶的减少表明了这一点。
