University of Bologna, Bologna, Italy.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2012 Jun;113(6):766-72. doi: 10.1016/j.oooo.2011.12.007. Epub 2012 Mar 26.
This study aimed to see whether clinical healing after amalgam removal corresponds to histologic healing, i.e., a complete disappearance of any histologic sign of lichenoid lesion.
The study evaluated 64 patients with lichenoid lesions and at least one amalgam filling.
After amalgam removal, complete clinical healing was obtained in 14 patients (22%) and was significantly related to lesion topography (χ(2) 4.7; P < .05) and positive patch test (χ(2) 6.3; P < .01). Complete histologic healing was obtained in only 7 cases (50% of clinically healed patients), and was significantly related to the combination of positive patch test and strict contact with amalgams (Fisher's exact test P < .01).
Contact with amalgams and positive patch testing are good but not absolute indicators of the beneficial effect of amalgam replacement. In addition, complete clinical healing does not necessarily mean a disappearance of the histologic characteristics of OLL/OLP lesions.
本研究旨在观察银汞合金去除后临床愈合是否与组织学愈合相对应，即是否完全消除了苔藓样病损的任何组织学迹象。
该研究评估了 64 例患有苔藓样病损且至少有一个银汞合金填充物的患者。
在去除银汞合金后，14 名患者（22%）获得了完全的临床愈合，且与病变部位（χ²4.7；P<.05）和阳性斑贴试验（χ²6.3；P<.01）显著相关。仅在 7 例患者（临床愈合患者的 50%）中获得了完全的组织学愈合，且与阳性斑贴试验和与银汞合金的严格接触相结合显著相关（Fisher 确切检验 P<.01）。
接触银汞合金和阳性斑贴试验是银汞合金更换有益效果的良好但非绝对指标。此外，完全的临床愈合并不一定意味着 OLL/OLP 病变的组织学特征消失。
