Department of Oral Pathology, University of the Western Cape and National Health Laboratory Services, Tygerberg Hospital, Cape Town, South Africa.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2012 Jun;113(6):799-807. doi: 10.1016/j.oooo.2012.01.027.
The aim of this study was to evaluate a cost-effective oral liquid-based cytology screening test, Shandon Papspin (PS).
We compared the diagnostic accuracy of PS with surgical biopsy in 69 patients. Transepithelial cytology specimens were obtained with the use of cervical cytobrushes. Cytology specimens were graded and scored by using a novel oral cytologic grading and scoring system.
Histologic diagnosis of dysplasia or malignancy was made in 51/69 cases, and cytology identified 49/51 cases, with a sensitivity of 96% and specificity of 100%. The best cutoff value for distinguishing reactive/mildly dysplastic lesions from high grade/invasive squamous cell carcinoma was determined to be a cytologic score of 3, representing a sensitivity of 95% and specificity of 96%.
PS appears to be an accurate and economical test for detection of high-risk dysplasias and cancers, but the real significance of this method will be its diagnostic accuracy in studies focusing strictly on lesions with a low level of clinical concern.
本研究旨在评估一种具有成本效益的基于液体的口腔细胞学筛查试验，即 Shandon Papspin（PS）。
我们比较了 PS 与 69 例患者手术活检的诊断准确性。使用宫颈细胞刷获取跨上皮细胞学标本。使用新型口腔细胞学分级和评分系统对细胞学标本进行分级和评分。
组织学诊断为异型增生或恶性病变的有 51/69 例，细胞学诊断为 49/51 例，敏感性为 96%，特异性为 100%。区分反应性/轻度异型增生病变与高级别/浸润性鳞状细胞癌的最佳临界值为细胞学评分 3，敏感性为 95%，特异性为 96%。
PS 似乎是一种准确且经济的检测高危异型增生和癌症的方法，但该方法的真正意义将在于其在严格关注低临床关注水平病变的研究中的诊断准确性。
