Department of Dentistry, Vancouver General Hospital, British Columbia, Canada.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2012 Sep;114(3):358-64. doi: 10.1016/j.oooo.2012.06.008.
This study evaluated whether quantitative cytology (QC) can disclose abnormal DNA content (aneuploidy) and abnormal nuclear morphology of high-risk potentially malignant disorders (PMDs) of the oral mucosa found in the community in reference to clinicohistopathologic features.
A total of 171 patients at community-based clinic with suspicious oral lesions were evaluated with concurrent but independent histopathologic and QC assessments.
QC-positive results were associated with oral lesions with higher clinical risk factors: large size, nonhomogeneous surface texture, and located at high-risk anatomic sites. Only 3% of benign/reactive and 5% of low-risk PMDs were QC positive, while 92% of high-risk PMDs and 88% of squamous cell carcinomas (SCCs) were QC positive. The sensitivity and specificity of QC for detection of high-grade dysplasia/SCC were 89% and 97%.
QC could serve as an adjunctive tool for the detection of high-risk PMD/SCC requiring immediate clinical care.
本研究旨在评估定量细胞学（QC）是否可以揭示社区中发现的高风险潜在恶性病变（PMD）的口腔黏膜中异常的 DNA 含量（非整倍体）和异常核形态，并与临床病理特征进行比较。
共有 171 名在社区诊所就诊的疑似口腔病变患者同时接受了独立的组织病理学和 QC 评估。
QC 阳性结果与具有更高临床危险因素的口腔病变相关：病变较大、表面纹理不均匀以及位于高风险解剖部位。良性/反应性病变和低风险 PMD 中仅分别有 3%和 5%为 QC 阳性，而高风险 PMD 和鳞状细胞癌（SCC）中分别有 92%和 88%为 QC 阳性。QC 检测高级别上皮内瘤变/SCC 的敏感性和特异性分别为 89%和 97%。
QC 可以作为一种辅助工具，用于检测需要立即进行临床治疗的高风险 PMD/SCC。
