Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2012 Jan;113(1):134-41. doi: 10.1016/j.tripleo.2011.07.039. Epub 2012 Feb 3.
The objective of this study was to compare the prevalence of calcified carotid artery atheromas (CCAAs) on panoramic images of individuals (n = 31) with obstructive sleep apnea (OSA) with individuals (n = 117) with syndrome Z (SZ: OSA with concomitant metabolic syndrome [MetS]).
Images of patients with OSA or SZ referred from the Sleep Service to Dentistry were evaluated. Descriptive statistics and t tests (Bonferroni correction) were conducted to determine significant differences between atheroma prevalence and proatherogenic factors (age, apnea-hypopnea index, body mass index, lipid profile, blood pressure, glucose) between OSA and SZ groups.
Individuals with OSA had an atheroma prevalence of 35% and those with SZ 42% (P = .52). Individuals with SZ also had significantly more severe atherogenic profiles (obesity, dyslipidemia, hyperglycemia) than OSA patients (P ≤ .05). Greatest CCAA prevalence (63%) was evidenced by SZ patients with severe OSA and moderate MetS.
Individuals with SZ have significantly greater atherogenic burden and slightly higher prevalence of CCAAs when compared with individuals with OSA.
本研究旨在比较阻塞性睡眠呼吸暂停（OSA）患者（n=31）与伴有代谢综合征（MetS）的 OSA 患者（综合征 Z，SZ：OSA 合并代谢综合征）的全景图像中存在钙化颈动脉粥样硬化（CCAAs）的患病率。
对来自睡眠科转诊至牙科的 OSA 或 SZ 患者的图像进行评估。采用描述性统计和 t 检验（Bonferroni 校正）来确定 OSA 和 SZ 组之间动脉粥样硬化患病率和促动脉粥样硬化因素（年龄、呼吸暂停低通气指数、体重指数、血脂谱、血压、血糖）之间的差异。
OSA 患者的动脉粥样硬化患病率为 35%，SZ 患者为 42%（P=.52）。SZ 患者的动脉粥样硬化性特征（肥胖、血脂异常、高血糖）也比 OSA 患者更为严重（P≤.05）。在严重 OSA 和中度 MetS 的 SZ 患者中，动脉粥样硬化的患病率最高（63%）。
与 OSA 患者相比，SZ 患者的促动脉粥样硬化负担明显更大，且 CCAAs 的患病率略高。
