Division of Neuropsychiatry, Department of Psychiatry, University Hospitals of Geneva, Geneva, Switzerland; Department of Neuroscience, University of Geneva, Geneva, Switzerland.
Neurosci Biobehav Rev. 2012 Sep;36(8):1934-51. doi: 10.1016/j.neubiorev.2012.05.010. Epub 2012 Jun 2.
The mesolimbic dopaminergic system (ML-DA) allows adapted interactions with the environment and is therefore of critical significance for the individual's survival. The ML-DA system is implicated in reward and emotional functions, and it is perturbed in schizophrenia, addiction, and depression. The ML-DA reward system is not only recruited during wakeful behaviors, it is also active during sleep. Here, we introduce the Reward Activation Model (RAM) for sleep and dreaming, according to which activation of the ML-DA reward system during sleep contributes to memory processes, to the regulation of rapid-eye movement (REM) sleep, and to the generation and motivational content of dreams. In particular, the engagement of ML-DA and associated limbic structures prioritizes information with high emotional or motivational relevance for (re)processing during sleep and dreaming. The RAM provides testable predictions and has clinical implications for our understanding of the pathogenesis of major depression and addiction.
中脑边缘多巴胺系统（ML-DA）允许与环境进行适应性交互，因此对个体的生存至关重要。ML-DA 系统与奖励和情绪功能有关，在精神分裂症、成瘾和抑郁症中受到干扰。ML-DA 奖励系统不仅在清醒行为期间被招募，它在睡眠期间也很活跃。在这里，我们介绍了用于睡眠和做梦的奖励激活模型（RAM），根据该模型，睡眠期间 ML-DA 奖励系统的激活有助于记忆过程、快速眼动（REM）睡眠的调节，以及梦境的产生和动机内容。特别是，ML-DA 的参与和相关的边缘结构优先处理具有高情绪或动机相关性的信息，以便在睡眠和做梦期间进行（重新）处理。RAM 提供了可测试的预测，并对我们理解重度抑郁症和成瘾的发病机制具有临床意义。
