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[The modelling of the multiple drug resistance of the malarial parasites. 1. The combined resistance of Plasmodium berghei to chloroquine and fansidar].

作者信息

Khanmirzoev F I, Kulikovskaia I M, Dadasheva N R, Rabinovich S A

出版信息

Med Parazitol (Mosk). 1990 Sep-Oct(5):60-3.

PMID:2266909
Abstract

Using a recurrent technique, P. berghei isolate resistant to chloroquine-fansidar combination is formed in golden hamsters. The isolate resistant to chloroquine-fansidar combination was 4 times less sensitive to chloroquine, 2 times less sensitive to fansidar and its combinations, 2 times less sensitive to sulfadoxine, 31 times less sensitive to pyrimethamine, as compared to the baseline isolate LNK65 P. berghei characterized by naturally reduced sensitivity to chloroquine.

摘要

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