Medical Faculty, Department of Diagnostic and Interventional Radiology, University Düsseldorf, Moorenstr. 5, 40225 Düsseldorf, Germany.
Eur J Nucl Med Mol Imaging. 2012 Sep;39(9):1435-40. doi: 10.1007/s00259-012-2152-6. Epub 2012 Jun 5.
The aim of this study was to evaluate whether a virtual 3-D (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT panendoscopy is feasible and can be used for noninvasive imaging of the upper airways and pharyngeal/laryngeal tumours.
From (18)F-FDG PET/CT data sets of 40 patients (29 men, 11 women; age 61 ± 9 years) with pharyngeal or laryngeal malignancies virtual 3-D (18)F-FDG PET/CT panendoscopies were reconstructed and the image processing time was measured. The feasibility of assessing the oral cavity, nasopharynx, tongue base, soft palate, pharyngeal tonsils, epiglottis, aryepiglottic folds, piriform sinus, postcricoid space, glottis, subglottis, trachea, bronchi and oesophagus and of detecting primary tumours was tested. Results of fibre-optic bronchoscopy and histology served as the reference standard.
The nasopharynx, tongue base, soft palate, pharyngeal tonsils, epiglottis, subglottis and the tracheobronchial tree were accessible in all 40, and the aryepiglottic folds, posterior hypopharyngeal wall, postcricoid space, piriform sinus, glottis, oral cavity and oesophagus in 37, 37, 37, 37, 33, 16 and 0 patients, respectively. In all 12 patients with restricted fibre-optic evaluation due to being primarily intubated, the subglottis was accessible via virtual panendoscopy. The primary tumour was depicted in 36 of 40 patients (90 %). The mean processing time for virtual (18)F-FDG PET/CT panendoscopies was 145 ± 98 s.
Virtual (18)F-FDG PET/CT panendoscopy of the upper airways is technically feasible and can detect pharyngeal and laryngeal malignancies. This new tool can aid in the complete evaluation of the subglottic space in intubated patients and may be used for planning optical panendoscopies, biopsies and surgery in the future.
本研究旨在评估虚拟三维（18）F-氟脱氧葡萄糖（FDG）正电子发射断层扫描（PET）/CT 全内镜检查是否可行，能否用于上气道和咽/喉肿瘤的无创成像。
从 40 例（29 名男性，11 名女性；年龄 61 ± 9 岁）咽或喉恶性肿瘤的（18）F-FDG PET/CT 数据集中，重建了虚拟三维（18）F-FDG PET/CT 全内镜，并测量了图像处理时间。评估了口腔、鼻咽、舌根、软腭、咽扁桃体、会厌、杓会厌皱襞、梨状隐窝、环后区、声门、声门下区、气管、支气管和食管，以及检测原发性肿瘤的可行性。纤维支气管镜和组织学检查结果作为参考标准。
40 例患者均能检查到鼻咽、舌根、软腭、咽扁桃体、会厌、声门下区和气管支气管树，37 例患者能检查到杓会厌皱襞、后咽壁、环后区、梨状隐窝、声门、口腔和食管，37 例患者能检查到软腭，37 例患者能检查到会厌，33 例患者能检查到声门，16 例患者能检查到口腔，0 例患者能检查到食管。在 12 例因主要插管而限制纤维镜评估的患者中，所有患者的声门下区均可通过虚拟全内镜检查。40 例患者中有 36 例（90%）显示原发性肿瘤。虚拟（18）F-FDG PET/CT 全内镜检查的平均处理时间为 145 ± 98 s。
上气道虚拟（18）F-FDG PET/CT 全内镜检查技术上是可行的，可以检测咽和喉的恶性肿瘤。这种新工具可以帮助评估插管患者的声门下区，也可以用于未来的光学全内镜检查、活检和手术计划。
