Department of Ophthalmology, Houju Memorial Hospital, Nomi, Japan.
Jpn J Ophthalmol. 2012 Jul;56(4):346-53. doi: 10.1007/s10384-012-0155-2. Epub 2012 Jun 7.
To compare the drug efficacy of four prostaglandin analogues (PGAs) by bilateral treatment in normal subjects.
Three consecutive studies comparing latanoprost to three other PGAs (travoprost, tafluprost and bimatoprost) were performed in 24 healthy subjects. Each study was separated by a washout period of over 6 weeks. In each study, two drugs were randomly assigned to one eye of each subject. Study subjects instilled the assigned medication at 9:00 p.m. every day for 2 weeks. The same masked investigator measured intraocular pressure (IOP) at 9:00 a.m., 1:00 p.m. and 5:00 p.m. at baseline and repeated measurements on days 7 and 14. The differences in IOP reduction were compared between the drugs.
Mean diurnal IOP reduction with latanoprost on days 7 and 14 was similar to that with travoprost and tafluprost, but was significantly lower than that with bimatoprost. The association of the mean diurnal IOP reduction between latanoprost and bimatoprost on day 14 (r (2) = 0.25) was weak, in remarkable contrast to the strong association between latanoprost and travoprost (r (2) = 0.81) and between latanoprost and tafluprost (0.82).
The short-term bilateral treatment revealed a different IOP-lowering efficacy of bimatoprost compared to other PGAs in healthy subjects.
比较四种前列腺素类似物（PGAs）在正常受试者双侧治疗的药物疗效。
在 24 名健康受试者中进行了三项连续研究，将拉坦前列素与另外三种 PGAs（曲伏前列素、他氟前列素和贝美前列素）进行比较。每项研究之间有超过 6 周的洗脱期。在每项研究中，两种药物随机分配给每个受试者的一只眼睛。研究对象每天晚上 9 点滴注分配的药物，持续 2 周。同一位蒙眼研究者在基线和第 7 天和第 14 天的上午 9 点、下午 1 点和 5 点测量眼压（IOP）。比较药物之间 IOP 降低的差异。
拉坦前列素在第 7 天和第 14 天的日间平均 IOP 降低与曲伏前列素和他氟前列素相似，但明显低于贝美前列素。第 14 天拉坦前列素和贝美前列素之间平均日间 IOP 降低的相关性（r (2) = 0.25）较弱，与拉坦前列素和曲伏前列素（r (2) = 0.81）和拉坦前列素和他氟前列素（0.82）之间的强相关性形成鲜明对比。
短期双侧治疗显示，在健康受试者中，贝美前列素与其他 PGAs 的降眼压疗效不同。
