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酰基辅酶A结合蛋白（ACBP）及其与脂肪酸结合蛋白（FABP）的关系：综述。

Acyl-CoA-binding protein (ACBP) and its relation to fatty acid-binding protein (FABP): an overview.

作者信息

Knudsen J

机构信息

Institute of Biochemistry, Odense University, Denmark.

出版信息

Mol Cell Biochem. 1990;98(1-2):217-23. doi: 10.1007/BF00231387.

DOI:10.1007/BF00231387
PMID:2266962
Abstract

Acyl-CoA-binding protein is a 10 Kd protein which binds medium- and long-chain acyl-CoA esters with high affinity. The concentration in liver is 2-4 times the acyl-CoA concentration. ACBP has much greater affinity for acyl-CoA than FABP. FABP from bovine heart and liver is unable to compete with multilamellar liposomes, Lipidex and microsomal membrane in binding acyl-CoA esters, whereas ACBP effectively extracts acyl-CoA from all those sources. Previously published results on the effect of FABP on acyl-CoA metabolism need to be reevaluated due to possible contamination with ACBP. Recently it was discovered that ACBP is identical to a putative neurotransmitter diazepam binding inhibitor. The possibility therefore exists that ACBP has more than one function.

摘要

酰基辅酶A结合蛋白是一种10千道尔顿的蛋白质，它能以高亲和力结合中链和长链酰基辅酶A酯。肝脏中的浓度是酰基辅酶A浓度的2至4倍。ACBP对酰基辅酶A的亲和力比脂肪酸结合蛋白（FABP）大得多。来自牛心脏和肝脏的FABP在结合酰基辅酶A酯时无法与多层脂质体、Lipidex和微粒体膜竞争，而ACBP能有效地从所有这些来源中提取酰基辅酶A。由于可能被ACBP污染，之前发表的关于FABP对酰基辅酶A代谢影响的结果需要重新评估。最近发现ACBP与一种假定的神经递质地西泮结合抑制剂相同。因此，ACBP有可能具有不止一种功能。

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2
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本文引用的文献

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Transacylation as a chain-termination mechanism in fatty acid synthesis by mammalian fatty acid synthetase. Synthesis of medium-chain-length (C8-C12) acyl-CoA esters by goat mammary-gland fatty acid synthetase.转酰基作用作为哺乳动物脂肪酸合成酶催化脂肪酸合成过程中的链终止机制。山羊乳腺脂肪酸合成酶催化中链长度（C8 - C12）酰基辅酶A酯的合成。
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Interaction of fatty acids, acyl-CoA derivatives and retinoids with microsomal membranes: effect of cytosolic proteins.脂肪酸、酰基辅酶A衍生物和类视黄醇与微粒体膜的相互作用：胞质蛋白的影响。
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Carnitine palmitoyltransferase activities: effects of serum albumin, acyl-CoA binding protein and fatty acid binding protein.肉碱棕榈酰转移酶活性：血清白蛋白、酰基辅酶A结合蛋白和脂肪酸结合蛋白的影响
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Historic overview of studies on fatty acid-binding proteins.
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Mol Cell Biochem. 1990;98(1-2):237-51. doi: 10.1007/BF00231390.
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Molecular cloning of the gene for the yeast homolog (ACB) of diazepam binding inhibitor/endozepine/acyl-CoA-binding protein.地西泮结合抑制剂/内源性苯二氮䓬/酰基辅酶A结合蛋白的酵母同源物（ACB）基因的分子克隆
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Fatty-acid-binding proteins. Occurrence of two fatty-acid-binding proteins in bovine liver cytosol and their binding of fatty acids, cholesterol, and other lipophilic ligands.
脂肪酸结合蛋白。牛肝细胞溶质中两种脂肪酸结合蛋白的存在及其与脂肪酸、胆固醇和其他亲脂性配体的结合。
Hoppe Seylers Z Physiol Chem. 1984 Mar;365(3):365-76. doi: 10.1515/bchm2.1984.365.1.365.
4
Triacylglycerol synthesis in goat mammary gland. The effect of ATP, Mg2+ and glycerol 3-phosphate on the esterification of fatty acids synthesized de novo.山羊乳腺中三酰甘油的合成。ATP、Mg2+和3-磷酸甘油对从头合成的脂肪酸酯化作用的影响。
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On a brain polypeptide functioning as a putative effector for the recognition sites of benzodiazepine and beta-carboline derivatives.关于一种脑多肽作为苯二氮䓬和β-咔啉衍生物识别位点的假定效应器的研究。
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Isolation, characterization, and purification to homogeneity of an endogenous polypeptide with agonistic action on benzodiazepine receptors.一种对苯二氮䓬受体具有激动作用的内源性多肽的分离、特性鉴定及纯化至均一性。
Proc Natl Acad Sci U S A. 1983 Jun;80(11):3531-5. doi: 10.1073/pnas.80.11.3531.
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Cytosolic modulators of activities of microsomal enzymes of cholesterol biosynthesis. Effects of Acyl-CoA inhibition and cytosolic Z-protein.胆固醇生物合成微粒体酶活性的胞质调节剂。酰基辅酶A抑制和胞质Z蛋白的作用。
Biochim Biophys Acta. 1983 Mar 22;751(1):41-51. doi: 10.1016/0005-2760(83)90255-2.
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The binding of long chain fatty acid CoA to Z, a cytoplasmic protein present in liver and other tissues of the rat.
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Extraction of tissue long-chain acyl-CoA esters and measurement by reverse-phase high-performance liquid chromatography.组织长链酰基辅酶A酯的提取及反相高效液相色谱法测定
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Function and regulation of hepatic and intestinal fatty acid binding proteins.肝脏和肠道脂肪酸结合蛋白的功能与调节
Chem Phys Lipids. 1985 Aug 30;38(1-2):95-114. doi: 10.1016/0009-3084(85)90060-x.