Pelclová D, Rössner P, Picková J
Teaching Hospital, Prague, Czechoslovakia.
Mutat Res. 1990 Dec;245(4):299-303. doi: 10.1016/0165-7992(90)90160-l.
Chromosome analysis was carried out in peripheral lymphocytes of 3 groups of workers. In 42 rotogravure printers exposed to rotogravure printing dyes and highly purified toluene at working air concentrations in the range of 104-1170 ppm (390-4380 mg/m3) for 13 years on average, an increased incidence of aberrant cells and chromatid breaks was observed. In 28 office and technical employees of the same plant, more than half of whom worked 2 h daily in the rotogravure workshop, an increased percentage of aberrant cells and chromatid breaks was also found. The difference between the 2 groups working in the printing plant and 32 controls was highly significant. The high incidence of aberrations could be explained by the exposure to toluene, but the influence of rotogravure printing dyes cannot be excluded. Smoking and high air pollution in the urban area were contributing factors in all 3 groups.
对3组工人的外周淋巴细胞进行了染色体分析。在42名轮转凹版印刷工人中，他们平均在工作环境空气中甲苯浓度为104 - 1170 ppm（390 - 4380毫克/立方米）的条件下接触轮转凹版印刷染料和高纯度甲苯达13年，观察到异常细胞和染色单体断裂的发生率增加。在同一工厂的28名办公室和技术人员中，其中一半以上每天在轮转凹版印刷车间工作2小时，也发现异常细胞和染色单体断裂的百分比增加。在印刷厂工作的这两组工人与32名对照组之间的差异非常显著。畸变的高发生率可以用接触甲苯来解释，但不能排除轮转凹版印刷染料的影响。吸烟和市区的高空气污染是所有3组中的促成因素。
