Pelclová D, Rössner P, Pícková J, Hykes P
Klinika nemocí z povolání fakultní nemocnice 2 s fakultní poliklinikou UNZ UNV hl. m. Prahy.
Cas Lek Cesk. 1990 Aug 10;129(32):1002-3.
Using cytogenetic analysis of peripheral lymphocytes the authors examined three groups of subjects: 42 rotogravure printers exposed to toluene in concentrations of 400-4400 mg.m-3 for a mean period of 13 years, 28 administrative employees of the printing plant exposed to low concentrations of toluene (8-16 mg.m-3) in their offices, whereby more than half of them spent on average two hours in the photogravure workshop, and 32 control subjects. In the printers 3.64% subjects, in the office staff 3.32% aberrant cells were found. The difference between the control group and the two groups from the printing plant was highly significant as regards the number of aberrant cells (P less than 0.005) and chromatid breaks and number of breaks per cell. The higher frequency of aberrant cells in probably associated with exposure to toluene, gravure printing dyes and in all three groups also with the highly contaminated communal atmosphere.
作者通过对周围淋巴细胞进行细胞遗传学分析，研究了三组对象：42名轮转凹版印刷工人，平均13年暴露于浓度为400 - 4400毫克/立方米的甲苯环境中；28名印刷厂行政员工，他们在办公室暴露于低浓度甲苯（8 - 16毫克/立方米）环境中，其中一半以上的人平均每天在照相凹版车间待两小时；以及32名对照对象。在印刷工人中，发现3.64%的对象存在异常细胞，在办公室职员中这一比例为3.32%。就异常细胞数量（P小于0.005）、染色单体断裂以及每个细胞的断裂数量而言，对照组与印刷厂的两组对象之间差异极为显著。异常细胞的较高频率可能与接触甲苯、凹版印刷染料有关，而且在所有三组对象中还与高度污染的公共环境有关。
