表现为持续性肺动脉高压的新生儿甲状腺毒症
Neonatal thyrotoxicosis presenting as persistent pulmonary hypertension.
作者信息
Obeid Rawad, Kalra Vaneet Kumar, Arora Prem, Quist Felix, Moltz Kathleen C, Chouthai Nitin Shashikant
机构信息
The Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit Medical Center, Children's Hospital of Michigan, Detroit, Michigan, USA.
出版信息
BMJ Case Rep. 2012 May 30;2012:bcr0220125939. doi: 10.1136/bcr.02.2012.5939.
Abstract
Neonatal hyperthyroidism is a rare condition caused either by transplacental passage of thyroid-stimulating immunoglobulins from a mother with Graves' disease or by activating mutations of the thyrotropin receptors and α-subunit of G-protein. The clinical features may vary. We report a case of neonatal thyrotoxicosis in an infant born to a mother with Graves' disease, who presented with cardiorespiratory failure and persistent pulmonary hypertension (PPHN). PPHN resolved with specific antithyroid treatment and extracorporeal membrane oxygenation was not required.
摘要
新生儿甲状腺功能亢进症是一种罕见的病症，其病因要么是患有格雷夫斯病的母亲的甲状腺刺激免疫球蛋白经胎盘传递，要么是促甲状腺激素受体和G蛋白α亚基的激活突变。临床特征可能各不相同。我们报告一例患有格雷夫斯病的母亲所生婴儿的新生儿甲状腺毒症病例，该婴儿出现心肺功能衰竭和持续性肺动脉高压（PPHN）。通过特异性抗甲状腺治疗，PPHN得到缓解，无需进行体外膜肺氧合。
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