新生儿甲亢伴母亲甲状腺功能减退症。
Neonatal thyrotoxicosis with maternal hypothyroidism.
机构信息
Department of Endocrinology, Manipal Academy of Higher Education (MAHE), Kasturba Medical College Manipal, Udupi, Karnataka, India.
Department of Endocrinology, Manipal Academy of Higher Education (MAHE), Kasturba Medical College Manipal, Udupi, Karnataka, India
出版信息
BMJ Case Rep. 2022 Mar 9;15(3):e247865. doi: 10.1136/bcr-2021-247865.
Abstract
Neonatal Graves' is uncommon, but a potentially fatal condition caused by transplacental transfer of thyroid stimulating immunoglobulin (TSI). It is seen in 1%-5% of infants born to a mother with Graves' disease. Here, we report a unique case of transient neonatal thyrotoxicosis with positive TSI in a premature neonate born to the mother with primary hypothyroidism. A short course of antithyroid drug treatment leads to significant clinical and biochemical improvement followed by complete recovery.
摘要
新生儿 Graves 病罕见，但却是一种潜在致命的疾病，由甲状腺刺激免疫球蛋白（TSI）经胎盘转移引起。该病在患有 Graves 病的母亲所生的 1%-5%婴儿中可见。在此，我们报告了一例罕见病例，即原发性甲状腺功能减退症母亲所生早产儿出现短暂性新生儿甲状腺毒症和 TSI 阳性。短期抗甲状腺药物治疗可显著改善临床和生化指标，随后完全恢复。
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