阿达木单抗治疗难治性复发性多软骨炎后发生Sweet综合征。
Sweet's syndrome after adalimumab therapy for refractory relapsing polychondritis.
作者信息
Keidel Sarah, McColl Aubretia, Edmonds Sally
机构信息
Department of Rheumatology, Stoke Mandeville Hospital, Aylesbury, UK.
出版信息
BMJ Case Rep. 2011 Dec 21;2011:bcr1020114935. doi: 10.1136/bcr.10.2011.4935.
Abstract
Relapsing polychondritis and Sweet's syndrome are rare systemic inflammatory conditions. The authors present a patient who developed Sweet's syndrome 1 week after adalimumab therapy for refractory relapsing polychondritis. Coexistent relapsing polychondritis and Sweet's syndrome is rare, however, is likely to represent a true disease association and signifies a high risk of myelodysplasia. Antitumour necrosis factor α (TNFα) therapy is a treatment option in both relapsing polychondritis and Sweet's syndrome, and switching anti-TNFα agents may be feasible in the event of adverse reaction.
摘要
复发性多软骨炎和Sweet综合征是罕见的全身性炎症性疾病。作者报告了一名难治性复发性多软骨炎患者，在接受阿达木单抗治疗1周后出现了Sweet综合征。复发性多软骨炎和Sweet综合征同时存在的情况罕见，但可能代表一种真正的疾病关联，提示骨髓发育异常的高风险。抗肿瘤坏死因子α（TNFα）治疗是复发性多软骨炎和Sweet综合征的一种治疗选择，出现不良反应时更换抗TNFα药物可能可行。
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本文引用的文献
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Acta Derm Venereol. 2008;88(5):517-9. doi: 10.2340/00015555-0488.
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Prolonged response to anti-tumour necrosis factor treatment with adalimumab (Humira) in relapsing polychondritis complicated by aortitis.阿达木单抗（修美乐）治疗复发性多软骨炎合并主动脉炎时的长期应答。
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Treatment of recurrent Sweet's syndrome with coexisting rheumatoid arthritis with the tumor necrosis factor antagonist etanercept.使用肿瘤坏死因子拮抗剂依那西普治疗合并类风湿性关节炎的复发性Sweet综合征。
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