Min Byung-Dal, Kang Ho-Won, Kim Won-Tae, Kim Yong-June, Yun Seok Joong, Lee Sang Cheol, Kim Wun-Jae
Department of Urology, Chungbuk National University College of Medicine, Cheongju, Korea.
Korean J Urol. 2012 May;53(5):371-4. doi: 10.4111/kju.2012.53.5.371. Epub 2012 May 18.
A 69-year-old man with castration-resistant prostate cancer (CRPC) received docetaxel and a corticosteroid. After the third cycle of docetaxel administration, he presented with dyspnea, cough, sputum, and fever of 39.2℃. The chest X-ray and chest computed tomography (CT) revealed a diffuse reticulonodular shadow in both lungs, which suggested interstitial pneumonitis. Initially, we used empiric broad-spectrum antibiotics and high-dose corticosteroids. However, his condition progressively became worse and he was transferred to the intensive care unit, intubated, and placed on mechanical ventilation. He died 4 days after hospital admission. Here we report this case of fatal interstitial pneumonitis after treatment with docetaxel for CRPC. We briefly consider docetaxel-induced pneumonitis to make physicians aware of the possibility of pulmonary toxicity so that appropriate treatment can be begun as soon as possible.
一名69岁的去势抵抗性前列腺癌（CRPC）患者接受了多西他赛和一种皮质类固醇治疗。在多西他赛给药的第三个周期后，他出现了呼吸困难、咳嗽、咳痰以及39.2℃的发热。胸部X线和胸部计算机断层扫描（CT）显示双肺弥漫性网状结节阴影，提示间质性肺炎。起初，我们使用了经验性广谱抗生素和大剂量皮质类固醇。然而，他的病情逐渐恶化，被转入重症监护病房，进行了气管插管并接受机械通气。他在入院4天后死亡。在此我们报告这例CRPC患者接受多西他赛治疗后发生致命性间质性肺炎的病例。我们简要探讨多西他赛诱发的肺炎，以使医生意识到肺部毒性的可能性，从而能够尽早开始适当的治疗。
