Os'kina N A, Boiarskikh U A, Lazarev A F, Petrova V D, Ganov D I, Tonacheva O G, Lifshits G I, Filipenko M L
Mol Biol (Mosk). 2012 Mar-Apr;46(2):234-41.
Compelling evidence demonstrates chromosome 8q24 as a prostate cancer susceptibility locus. In present work we studied whether the common variants of 8q24 region, rs6983267 and rs1447295, were associated with the sporadic prostate cancer risk in the Russian population. Polymorphisms were genotyped in 393 case and 384 control Russian Caucasian men from Siberia region. The A allele of rs1447295 was significantly associated with the risk of prostate cancer (OR[CI 95%] = 1.74 [1.26-2.4], p = 7.8 x 10(-4)). A common G-A haplotype for rs6983267 - rs1447295 also showed an association with prostate cancer risk in Russian population (OR[CI 95%] = 2.03 [1.1 - 3.75], p = 0.02). We performed a meta-analysis combining our results with previous studies to evaluate the association between studied SNPs and prostate cancer risk. Meta-analysis has strongly supported the association for these SNPs (p < 10(-6)). Accordingly our study confirms the association between chromosome 8q24 and prostate cancer risk.
有力证据表明8号染色体q24区域是前列腺癌易感位点。在本研究中，我们探究了8q24区域的常见变异rs6983267和rs1447295是否与俄罗斯人群散发性前列腺癌风险相关。对来自西伯利亚地区的393例俄罗斯白种人前列腺癌患者和384例对照者的多态性进行了基因分型。rs1447295的A等位基因与前列腺癌风险显著相关（OR[95%置信区间]=1.74[1.26 - 2.4]，p = 7.8×10⁻⁴）。rs6983267 - rs1447295的常见G - A单倍型在俄罗斯人群中也显示出与前列腺癌风险相关（OR[95%置信区间]=2.03[1.1 - 3.75]，p = 0.02）。我们进行了一项荟萃分析，将我们的结果与之前的研究相结合，以评估所研究的单核苷酸多态性（SNP）与前列腺癌风险之间的关联。荟萃分析有力支持了这些SNP与前列腺癌的关联（p < 10⁻⁶）。因此，我们的研究证实了8号染色体q24与前列腺癌风险之间的关联。
