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一项评估儿童镇痛药物适口性的前瞻性研究。

A prospective study to assess the palatability of analgesic medicines in children.

机构信息

Academic Division of Child Health, The Medical School, Royal Derby Hospital, University of Nottingham, Derby, UK.

出版信息

J Adv Nurs. 2013 Mar;69(3):655-63. doi: 10.1111/j.1365-2648.2012.06050.x. Epub 2012 Jun 7.

Abstract

AIM

This study examined children's opinions on the taste of three analgesic medicines: paracetamol, ibuprofen and codeine.

BACKGROUND

Many medicines for children are unpleasant and unacceptable. Research has shown that children's taste preferences differ to adults, in whom palatability is often tested. Little British research exists on children's opinions on the palatability of medicines. This study aimed to address this gap in knowledge.

DESIGN

Prospective observational study.

METHODS

Between May-September 2008, hospital inpatients aged 5-16 years rated the taste of required analgesics on a 100-mm visual analogue scale. This incorporated a 5-point facial hedonic scale. They were also asked their favourite flavour and colour for a medicine.

RESULTS

A total of 159 children took part. Eighty-five males (53·5%) and 74 females (46·5%). The median age was 8 years (Inter-quartile range 6-11). The taste of ibuprofen was significantly preferred to paracetamol or codeine. Significant differences were observed depending if the medicine rated was taken first or second (for example pre-medication with paracetamol and ibuprofen). Younger children (5-8 years) were more likely to choose the extremes of the scale when grading than older children were. Preferred flavours on questioning were strawberry 44% and banana 17%. Favourite colours were pink 25·8% and red 20·8%, with girls more likely to choose pink and boys blue.

CONCLUSION

Ibuprofen was the most palatable analgesic medicine tested. Children reported they preferred fruit flavours and colour was sex dependent. Nurses when administering two medicines together should consider giving the least palatable first, for example paracetamol before ibuprofen for pre-medication.

摘要

目的

本研究调查了儿童对三种镇痛药(扑热息痛、布洛芬和可待因)味道的看法。

背景

许多儿童用药味道不佳,难以接受。研究表明,儿童的味觉偏好与成年人不同,成年人通常测试的是适口性。英国关于儿童对药物适口性看法的研究很少。本研究旨在填补这一知识空白。

设计

前瞻性观察研究。

方法

2008 年 5 月至 9 月期间,医院住院的 5-16 岁儿童使用 100 毫米视觉模拟量表对所需镇痛药的味道进行评分。这包括了 5 分面部愉悦量表。他们还被问到他们最喜欢的药物口味和颜色。

结果

共有 159 名儿童参与。85 名男性(53.5%)和 74 名女性(46.5%)。中位数年龄为 8 岁(四分位距 6-11 岁)。与扑热息痛或可待因相比,布洛芬的味道明显更受青睐。观察到如果所评估的药物是第一种还是第二种药物(例如,扑热息痛和布洛芬的预用药),存在显著差异。年龄较小的儿童(5-8 岁)在评分时比年龄较大的儿童更倾向于选择量表的极端值。在询问时,最喜欢的口味是草莓 44%和香蕉 17%。最喜欢的颜色是粉色 25.8%和红色 20.8%,女孩更喜欢粉色,男孩更喜欢蓝色。

结论

布洛芬是测试过的最可口的镇痛药。儿童报告说他们更喜欢水果口味,颜色与性别有关。护士在同时使用两种药物时,应考虑先使用最不可口的药物,例如在预用药时先使用扑热息痛,再使用布洛芬。

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