Klingmann Viviane, Vallet Thibault, Münch Juliane, Stegemann Robin, Wolters Lena, Bosse Hans-Martin, Ruiz Fabrice
Department of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty, University Children's Hospital Düsseldorf, Moorenstrasse 5, 40225 Düsseldorf, Germany.
ClinSearch, 110 Avenue Pierre Brossolette, 92240 Malakoff, France.
Pharmaceutics. 2022 Jan 31;14(2):337. doi: 10.3390/pharmaceutics14020337.
Although medicine acceptability is likely to have a significant impact on the patient's adherence in pediatrics and therefore on therapy success, there is still little data even for common therapeutic areas. For analgesics/antipyretics, healthcare professionals face a wide variety of products and need knowledge to select the best adapted product for each patient. We investigated acceptability of those products most used at the University Children's Hospital Düsseldorf, Germany. Based on 180 real-life observer reports of medicine intake, we used the acceptability reference framework to score acceptability of six distinct medicines. Both ibuprofen and paracetamol tablets, mainly used in adolescents, were positively accepted. This was not the case for the solution for injection of metamizole sodium. Regarding syrups, mainly used in children under 6 years of age, ibuprofen flavored with strawberry and provided with an oral syringe was positively accepted, while paracetamol flavored with orange and provided with a measuring cup was not. Suppository appeared to be an alternative to oral liquids in infants and toddlers with palatability and administration issues. Differences appeared to be driven by dosage forms and formulations. These findings improve knowledge on acceptability drivers and might help formulating and prescribing better medicines for children.
尽管药物可接受性可能对儿科患者的依从性进而对治疗成功产生重大影响，但即使在常见治疗领域，相关数据仍然很少。对于止痛/退烧药，医疗保健专业人员面临各种各样的产品，需要具备相关知识才能为每个患者选择最合适的产品。我们调查了德国杜塞尔多夫大学儿童医院最常用的那些产品的可接受性。基于180份药物摄入的实际观察报告，我们使用可接受性参考框架对六种不同药物的可接受性进行评分。主要用于青少年的布洛芬片和对乙酰氨基酚片都获得了正面评价。而安乃近注射液则不然。至于主要用于6岁以下儿童的糖浆剂，带有草莓味并配有口服注射器的布洛芬糖浆获得了正面评价，而带有橙子味并配有量杯的对乙酰氨基酚糖浆则未获认可。栓剂似乎是存在口感和给药问题的婴幼儿口服液体的替代品。差异似乎是由剂型和配方驱动的。这些发现增进了我们对可接受性驱动因素的了解，可能有助于为儿童配制和开出处方更优质的药物。
