Department of Dermatology and Allergy, University of Bonn, Bonn, Germany.
Allergy. 2012 Aug;67(8):969-75. doi: 10.1111/j.1398-9995.2012.02845.x. Epub 2012 Jun 4.
The concept of disease modification has been introduced to define the therapeutic strategies aimed to break, stop, or reverse the natural course of a chronic invalidating disease. This strategy is tightly related to the biomarker-based stratification of affected patients using genetic and other biological markers. With regard to the progress in understanding the genetic background of atopic dermatitis (AD), its natural history and its pivotal role in the emergence of allergic asthma, the time is mature to foster the research field of biomarkers in AD and to consider the elaboration of disease-modifying strategies in the management of AD with the goal to stop or even reverse the atopic march.
疾病修正的概念已经被引入，以定义旨在打破、停止或逆转慢性致残性疾病自然进程的治疗策略。该策略与使用遗传和其他生物标志物对受影响患者进行基于生物标志物的分层密切相关。鉴于对特应性皮炎（AD）遗传背景、其自然史及其在过敏性哮喘出现中的关键作用的理解取得了进展，现在是时候促进 AD 生物标志物研究领域的发展，并考虑制定 AD 管理中的疾病修正策略，以阻止甚至逆转特应性进程。
