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微针遇见生物标志物：用于诊断和监测局部外部器官疾病的未来应用。

Where Microneedle Meets Biomarkers: Futuristic Application for Diagnosing and Monitoring Localized External Organ Diseases.

机构信息

School of Pharmacy, Queen's University Belfast, Belfast, BT97BL, UK.

Department of Pharmaceutical Science and Technology, Faculty of Pharmacy, Hasanuddin University, Makassar, 90245, Indonesia.

出版信息

Adv Healthc Mater. 2023 Feb;12(5):e2202066. doi: 10.1002/adhm.202202066. Epub 2022 Dec 5.

DOI:10.1002/adhm.202202066
PMID:36414019
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11468661/
Abstract

Extracellular tissue fluids are interesting biomatrices that have recently attracted scientists' interest. Many significant biomarkers for localized external organ diseases have been isolated from this biofluid. In the diagnostic and disease monitoring context, measuring biochemical entities from the fluids surrounding the diseased tissues may give more important clinical value than measuring them at a systemic level. Despite all these facts, pushing tissue fluid-based diagnosis and monitoring forward to clinical settings faces one major problem: its accessibility. Most extracellular tissue fluid, such as interstitial fluid (ISF), is abundant but hard to collect, and the currently available technologies are invasive and expensive. This is where novel microneedle technology can help tackle this significant obstacle. The ability of microneedle technology to minimally invasively access tissue fluid-containing biomarkers will enable ISF and other tissue fluid utilization in the clinical diagnosis and monitoring of localized diseases. This review attempts to present the current pursuit of the application of microneedle systems as a diagnostic and monitoring platform, along with the recent progress of biomarker detection in diagnosing and monitoring localized external organ diseases. Then, the potential use of various microneedles in future clinical diagnostics and monitoring of localized diseases is discussed by presenting the currently studied cases.

摘要

细胞外组织液是一种有趣的生物基质，最近引起了科学家的兴趣。许多局部外部器官疾病的重要生物标志物已从这种生物流体中分离出来。在诊断和疾病监测的背景下，测量患病组织周围液体中的生化物质可能比在系统水平上测量它们具有更重要的临床价值。尽管有这些事实，但将基于组织液的诊断和监测推向临床环境面临一个主要问题：其可及性。大多数细胞外组织液，如间质液（ISF），虽然丰富但难以收集，并且目前可用的技术具有侵入性且昂贵。这就是新型微针技术可以提供帮助的地方。微针技术能够微创地获取含有生物标志物的组织液，这将使 ISF 和其他组织液能够用于局部疾病的临床诊断和监测。本综述试图介绍微针系统作为诊断和监测平台的应用现状，以及生物标志物检测在局部外部器官疾病诊断和监测中的最新进展。然后，通过介绍目前研究的案例，讨论了各种微针在未来局部疾病临床诊断和监测中的潜在用途。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fcd/11468661/2bc3b5538a4e/ADHM-12-2202066-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fcd/11468661/f2beefe3893b/ADHM-12-2202066-g005.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fcd/11468661/10ddfd20e349/ADHM-12-2202066-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fcd/11468661/e4747ca5bf19/ADHM-12-2202066-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fcd/11468661/8ef4f07e7d41/ADHM-12-2202066-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fcd/11468661/21df9c860013/ADHM-12-2202066-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fcd/11468661/166bf8c34307/ADHM-12-2202066-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fcd/11468661/c33168b52223/ADHM-12-2202066-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fcd/11468661/d9075c5d5b53/ADHM-12-2202066-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fcd/11468661/f2730a2bcfcc/ADHM-12-2202066-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fcd/11468661/bf6c5f90dafa/ADHM-12-2202066-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fcd/11468661/2bc3b5538a4e/ADHM-12-2202066-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fcd/11468661/f2beefe3893b/ADHM-12-2202066-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fcd/11468661/3e6209164e59/ADHM-12-2202066-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fcd/11468661/10ddfd20e349/ADHM-12-2202066-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fcd/11468661/e4747ca5bf19/ADHM-12-2202066-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fcd/11468661/8ef4f07e7d41/ADHM-12-2202066-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fcd/11468661/21df9c860013/ADHM-12-2202066-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fcd/11468661/166bf8c34307/ADHM-12-2202066-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fcd/11468661/c33168b52223/ADHM-12-2202066-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fcd/11468661/d9075c5d5b53/ADHM-12-2202066-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fcd/11468661/f2730a2bcfcc/ADHM-12-2202066-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fcd/11468661/bf6c5f90dafa/ADHM-12-2202066-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fcd/11468661/2bc3b5538a4e/ADHM-12-2202066-g014.jpg

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